2. Apoptosis Autophagy
  3. c-Myc Autophagy
  4. IZCZ-3

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.

For research use only. We do not sell to patients.

IZCZ-3 Chemical Structure

IZCZ-3 Chemical Structure

CAS No. : 2223019-53-0

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Based on 3 publication(s) in Google Scholar

IZCZ-3 Related Antibodies

Top Publications Citing Use of Products

    IZCZ-3 purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Oct 21.  [Abstract]

    IZCZ-3 (0.5 μM; 24 h) co-operates with IFNγ to induce differentiation in NB4 cells.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity[1].

    IC50 & Target

    c-MYC transcription[1]
    In Vitro

    IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC50s of 3.3, 2.1，4.1, and 4.2 μM, respectively). IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC50=15.9 μM) and mouse mesangial cells (IC50=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells[1].
    IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    IZCZ-3 Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: SiHa, HeLa, Huh7, and A375 cancer cells (with overexpression of c-MYC protein) and in normal BJ fibroblasts and primary cultured mouse mesangial cells (with relatively low expression of c-MYC protein).
    Concentration: 2.1 μM-15.9 μM
    Incubation Time: 24 hours
    Result: IC50s of 3.3, 2.1，4.1, and 4.2 μM for SiHa, HeLa, Huh7, and A375 cancer cells; IC50s of 15.9 μM and 15.6 μM for BJ fibroblasts and mouse mesangial cells.

    Cell Cycle Analysis[1]

    Cell Line: SiHa cells
    Concentration: 0, 1.25, 2.5, and 5 μM
    Incubation Time: 12 hours
    Result: Induced an apparent accumulation of cells in the G0/G1 phase (increasing from 61% to 70%) in a dose-dependent manner.
    In Vivo

    IZCZ-3 (20, 10, and 5 mg/kg; intraperitoneally; every other day for 24 days) inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c nude mice (5 weeks old) bearing SiHa human cervical squamous cancer xenograft model[1]
    Dosage: 20, 10, and 5 mg/kg
    Administration: Treated intraperitoneally; every other day for 24 days
    Result: Treatment with 20, 10, and 5 mg/kg resulted in a significant reduction in tumor weight with tumor growth inhibition (TGI) of 69%, 64%, and 57%, respectively. Displayed time-dependent inhibition of tumor growth.
    Molecular Weight

    715.93

    Formula

    C46H49N7O
    CAS No.
    Appearance

    Solid

    Color

    Off-white to pink

    SMILES

    CN(CC1)CCN1C2=CC=C(C3=C(C4=CC=C(N5CCN(C)CC5)C=C4)N=C(C6=CC(C(C=CC=C7)=C7N8CC)=C8C=C6)N3C9=CC=C(OC)C=C9)C=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (6.98 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3968 mL 6.9839 mL 13.9678 mL
    5 mM 0.2794 mL 1.3968 mL 2.7936 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.3968 mL 6.9839 mL 13.9678 mL 34.9196 mL
    5 mM 0.2794 mL 1.3968 mL 2.7936 mL 6.9839 mL
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    IZCZ-3 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    IZCZ-32223019-53-0IZCZ3IZCZ 3c-MycAutophagyMycInhibitorinhibitorinhibit

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