2. Others
  3. Others
  4. KY-556

KY-556 is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases.

For research use only. We do not sell to patients.

KY-556 Chemical Structure

KY-556 Chemical Structure

CAS No. : 110816-78-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
100 mg USD 1500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

KY-556 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE KY-556

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KY-556 is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases.

In Vivo

The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

725.57

Formula

C33H38Cl2N2O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CCCCN)C(OC(COC1=C2C(C=C(C(OCC)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(OCC)=O)OC4=CC=C3)=O)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (114.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3782 mL 6.8911 mL 13.7823 mL
5 mM 0.2756 mL 1.3782 mL 2.7565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3782 mL 6.8911 mL 13.7823 mL 34.4557 mL
5 mM 0.2756 mL 1.3782 mL 2.7565 mL 6.8911 mL
10 mM 0.1378 mL 0.6891 mL 1.3782 mL 3.4456 mL
15 mM 0.0919 mL 0.4594 mL 0.9188 mL 2.2970 mL
20 mM 0.0689 mL 0.3446 mL 0.6891 mL 1.7228 mL
25 mM 0.0551 mL 0.2756 mL 0.5513 mL 1.3782 mL
30 mM 0.0459 mL 0.2297 mL 0.4594 mL 1.1485 mL
40 mM 0.0345 mL 0.1723 mL 0.3446 mL 0.8614 mL
50 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6891 mL
60 mM 0.0230 mL 0.1149 mL 0.2297 mL 0.5743 mL
80 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.4307 mL
100 mM 0.0138 mL 0.0689 mL 0.1378 mL 0.3446 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KY-556 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY-556110816-78-9N556KY556KY 556N 556N-556OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KY-556
Cat. No.:
HY-U00148
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.