Ledipasvir (diacetone) (Synonyms: GS-5885 (diacetone))

Cat. No.: HY-15602D: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

For research use only. We do not sell to patients.

Ledipasvir (diacetone) Chemical Structure

CAS No. : 1502655-48-2

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Other In-stock Forms of Ledipasvir (diacetone):

Ledipasvir Ledipasvir (acetone) Ledipasvir D-tartrate

Other Forms of Ledipasvir (diacetone):

32 Publications Citing Use of MCE Ledipasvir (diacetone)

: Ledipasvir (diacetone) purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2015 Jun;59(6):3482-92. [Abstract]; Assessment of HCV inhibition by DAAs from 3 classes using Western blot analysis. Jc1/Gluc2A virus-infected Huh-7.5.1 cells are treated with DMSO or the HCV inhibitors at concentrations of 100× EC₅₀ (DCV, 3.2 nM; LDV, 3 μM; DNV, 0.32 μM; SOF, 20 μM). Cell lysates are harvested at 8 hpt (C and D) or at 24 hpt (A and B) and blotted for NS5A (A and C) or core (B and D). Data are normalized to GAPDH and quantified as relative fold change with respect to DMSO.

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Description

In Vitro

Ledipasvir diacetone is considered the active ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

1005.16

Formula

C₅₅H₆₆F₂N₈O₈

CAS No.

1502655-48-2

SMILES

O=C(OC)N[C@H](C(N([C@H](C1=NC=C(C2=CC(C(F)(F)C3=C4C=CC(C5=CC=C6N=C([C@H]7N(C([C@@H](NC(OC)=O)C(C)C)=O)[C@]8([H])CC[C@@]7([H])C8)NC6=C5)=C3)=C4C=C2)N1)C9)CC%109CC%10)=O)C(C)C.CC(C)=O.CC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

Ledipasvir (diacetone) Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ledipasvir (diacetone)1502655-48-2GS-5885 (diacetone)HCVHepatitis C virusInhibitorinhibitorinhibit

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