2. Anti-infection
  3. HCV SARS-CoV
  4. Ledipasvir-d6

Ledipasvir-d6  (Synonyms: GS-5885-d6)

Cat. No.: HY-15602S Purity: ≥99.0%
COA Handling Instructions

Molarity Calculator

Ledipasvir-d6 is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM[3].

For research use only. We do not sell to patients.

Ledipasvir-d<sub>6</sub> Chemical Structure

Ledipasvir-d6 Chemical Structure

CAS No. : 2050041-12-6

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1 mg USD 350 In-stock
5 mg USD 950 In-stock
10 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ledipasvir-d6:

Ledipasvir-d6 Related Antibodies

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Description

Ledipasvir-d6 is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ledipasvir-d6 Related Antibodies
Molecular Weight

895.04

Formula

C49H48D6F2N8O6
CAS No.
Unlabeled CAS

1256388-51-8
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OC([2H])([2H])[2H])N[C@H](C(N([C@H](C1=NC=C(C2=CC(C(F)(F)C3=C4C=CC(C5=CC=C6N=C([C@H]7N(C([C@@H](NC(OC([2H])([2H])[2H])=O)C(C)C)=O)[C@]8([H])CC[C@@]7([H])C8)NC6=C5)=C3)=C4C=C2)N1)C9)CC%109CC%10)=O)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (55.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (55.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1173 mL 5.5863 mL 11.1727 mL
5 mM 0.2235 mL 1.1173 mL 2.2345 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.1173 mL 5.5863 mL 11.1727 mL 27.9317 mL
5 mM 0.2235 mL 1.1173 mL 2.2345 mL 5.5863 mL
10 mM 0.1117 mL 0.5586 mL 1.1173 mL 2.7932 mL
15 mM 0.0745 mL 0.3724 mL 0.7448 mL 1.8621 mL
20 mM 0.0559 mL 0.2793 mL 0.5586 mL 1.3966 mL
25 mM 0.0447 mL 0.2235 mL 0.4469 mL 1.1173 mL
30 mM 0.0372 mL 0.1862 mL 0.3724 mL 0.9311 mL
40 mM 0.0279 mL 0.1397 mL 0.2793 mL 0.6983 mL
50 mM 0.0223 mL 0.1117 mL 0.2235 mL 0.5586 mL
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Ledipasvir-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ledipasvir-d62050041-12-6GS-5885-d6HCVSARS-CoVHepatitis C virusSARS coronavirusInhibitorinhibitorinhibit

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