2. Vitamin D Related/Nuclear Receptor
  3. VD/VDR
  4. Lexacalcitol

Lexacalcitol  (Synonyms: KH1060)

Cat. No.: HY-32340 Purity: 99.42%
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Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.

For research use only. We do not sell to patients.

Lexacalcitol Chemical Structure

Lexacalcitol Chemical Structure

CAS No. : 131875-08-6

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5 mg USD 640 In-stock
10 mg USD 1024 In-stock
25 mg USD 2150 In-stock
50 mg USD 3440 In-stock
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Based on 1 publication(s) in Google Scholar

Lexacalcitol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].

In Vitro

Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lexacalcitol Related Antibodies
In Vivo

Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female spontaneously diabetic NOD mice[2]
Dosage: 0.5 mg/kg/2 days
Administration: Intraperitoneal injection
Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
Molecular Weight

460.69

Formula

C29H48O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]1(CCC/2)[C@](CC[C@@H]1[C@@H](C)OCCCC(CC)(CC)O)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (217.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1707 mL 10.8533 mL 21.7066 mL
5 mM 0.4341 mL 2.1707 mL 4.3413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1707 mL 10.8533 mL 21.7066 mL 54.2664 mL
5 mM 0.4341 mL 2.1707 mL 4.3413 mL 10.8533 mL
10 mM 0.2171 mL 1.0853 mL 2.1707 mL 5.4266 mL
15 mM 0.1447 mL 0.7236 mL 1.4471 mL 3.6178 mL
20 mM 0.1085 mL 0.5427 mL 1.0853 mL 2.7133 mL
25 mM 0.0868 mL 0.4341 mL 0.8683 mL 2.1707 mL
30 mM 0.0724 mL 0.3618 mL 0.7236 mL 1.8089 mL
40 mM 0.0543 mL 0.2713 mL 0.5427 mL 1.3567 mL
50 mM 0.0434 mL 0.2171 mL 0.4341 mL 1.0853 mL
60 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9044 mL
80 mM 0.0271 mL 0.1357 mL 0.2713 mL 0.6783 mL
100 mM 0.0217 mL 0.1085 mL 0.2171 mL 0.5427 mL
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Lexacalcitol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lexacalcitol131875-08-6KH1060KH 1060KH-1060VD/VDRVitamin DVitamin D receptorantiproliferativecelldifferentiating1a,25-(OH)2D3immunosuppressiveauto-immunediseasespsoriasispreventiongraftrejectionInhibitorinhibitorinhibit

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