2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR Dopamine Transporter
  4. Lobeline hydrochloride

Lobeline hydrochloride  (Synonyms: α-Lobeline hydrochloride; L-Lobeline hydrochloride)

Cat. No.: HY-B0979 Purity: 99.98%
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Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation.

For research use only. We do not sell to patients.

Lobeline hydrochloride Chemical Structure

Lobeline hydrochloride Chemical Structure

CAS No. : 134-63-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water USD 27 In-stock
Solid
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50 mg USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Lobeline hydrochloride:

Lobeline hydrochloride Related Antibodies

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Description

Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation[1][2].

In Vitro

Lobeline (0.1-100 μM) hydrochloride evokes [3H]DA overflow calcium-independently[1].
Lobeline hydrochloride inhibits [3H]DA uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lobeline hydrochloride Related Antibodies
In Vivo

Lobeline (0.3-3.0 mg/kg; s.c.; single dose) hydrochloride decreases d-methamphetamine self-administration in rats model[3].
Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) hydrochloride specifically decreases responding for d-Methamphetamine in a noncompetitive manner, and increases tolerance development[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (200-250 g)[3]
Dosage: 0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration
Administration: Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration
Result: Decreased d-methamphetamine Self-Administration.
Clinical Trial
Molecular Weight

373.92

Formula

C22H28ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 6 mg/mL (16.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6744 mL 13.3718 mL 26.7437 mL
5 mM 0.5349 mL 2.6744 mL 5.3487 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

SDS (420 KB)

COA (247 KB) RP-HPLC (206 KB) LCMS (272 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6744 mL 13.3718 mL 26.7437 mL 66.8592 mL
5 mM 0.5349 mL 2.6744 mL 5.3487 mL 13.3718 mL
10 mM 0.2674 mL 1.3372 mL 2.6744 mL 6.6859 mL
15 mM 0.1783 mL 0.8915 mL 1.7829 mL 4.4573 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lobeline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lobeline134-63-4α-LobelineL-LobelinenAChRDopamine TransporterNicotinic acetylcholine receptorsDATSLC6A3Inhibitorinhibitorinhibit

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