Lorglumide sodium salt (Synonyms: CR-1409 sodium salt)

Name: Lorglumide sodium salt
Brand: MedChemExpress
SKU: HY-B1439B
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1439B Purity: 99.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist.

For research use only. We do not sell to patients.

Lorglumide sodium salt Chemical Structure

CAS No. : 1021868-76-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 37	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 37	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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CCKAR CCKBR

Biological Activity
Purity & Documentation
References
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Description

Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist^[1].

IC₅₀ & Target

CCK^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	289 nM Compound: Lorglumide Sodium	Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 3 days by MTT assay Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 3 days by MTT assay	10.1039/C6MD00052E
MAC13	IC₅₀	421 nM Compound: Lorglumide Sodium	Antiproliferative activity against mouse MAC13 cells assessed as reduction in cell viability after 3 days by MTT assay Antiproliferative activity against mouse MAC13 cells assessed as reduction in cell viability after 3 days by MTT assay	10.1039/C6MD00052E
MAC16	IC₅₀	861 nM Compound: Lorglumide Sodium	Antiproliferative activity against mouse MAC16 cells assessed as reduction in cell viability after 3 days by MTT assay Antiproliferative activity against mouse MAC16 cells assessed as reduction in cell viability after 3 days by MTT assay	10.1039/C6MD00052E
U-373MG ATCC	IC₅₀	> 5000 nM Compound: Lorglumide Sodium	Antiproliferative activity against human U373MG cells assessed as reduction in cell viability after 3 days by MTT assay Antiproliferative activity against human U373MG cells assessed as reduction in cell viability after 3 days by MTT assay	10.1039/C6MD00052E

Molecular Weight

481.39

Formula

C₂₂H₃₁Cl₂N₂NaO₄

CAS No.

1021868-76-7

Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(C=CC(C(NC(CCC(O[Na])=O)C(N(CCCCC)CCCCC)=O)=O)=C1)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (207.73 mM)

DMSO : 100 mg/mL (207.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0773 mL	10.3866 mL	20.7732 mL
5 mM	0.4155 mL	2.0773 mL	4.1546 mL
10 mM	0.2077 mL	1.0387 mL	2.0773 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (4.32 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (103.87 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.19%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB) HNMR (293 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Scarpignato C, et al. Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat. Br J Pharmacol. 1989 Mar;96(3):661-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.0773 mL	10.3866 mL	20.7732 mL	51.9329 mL
	5 mM	0.4155 mL	2.0773 mL	4.1546 mL	10.3866 mL
	10 mM	0.2077 mL	1.0387 mL	2.0773 mL	5.1933 mL
	15 mM	0.1385 mL	0.6924 mL	1.3849 mL	3.4622 mL
	20 mM	0.1039 mL	0.5193 mL	1.0387 mL	2.5966 mL
	25 mM	0.0831 mL	0.4155 mL	0.8309 mL	2.0773 mL
	30 mM	0.0692 mL	0.3462 mL	0.6924 mL	1.7311 mL
	40 mM	0.0519 mL	0.2597 mL	0.5193 mL	1.2983 mL
	50 mM	0.0415 mL	0.2077 mL	0.4155 mL	1.0387 mL
	60 mM	0.0346 mL	0.1731 mL	0.3462 mL	0.8655 mL
	80 mM	0.0260 mL	0.1298 mL	0.2597 mL	0.6492 mL
	100 mM	0.0208 mL	0.1039 mL	0.2077 mL	0.5193 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Lorglumide sodium salt Related Classifications

Metabolic Disease Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lorglumide1021868-76-7CR-1409CR1409CR 1409Cholecystokinin ReceptorCCK ReceptorInhibitorinhibitorinhibit

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Lorglumide sodium salt (Synonyms: CR-1409 sodium salt)

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Lorglumide sodium salt Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Cholecystokinin Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

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Dilution Calculator

Complete Stock Solution Preparation Table

Lorglumide sodium salt Related Classifications

Keywords:

Your Recently Viewed Products:

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