2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Losartan-d4

Losartan-d4  (Synonyms: DuP-753 d4)

Cat. No.: HY-17512S Purity: ≥99.0%
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Losartan-d4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

For research use only. We do not sell to patients.

Losartan-d<sub>4</sub> Chemical Structure

Losartan-d4 Chemical Structure

CAS No. : 1030937-27-9

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1 mg USD 210 In-stock
5 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Losartan-d4:

Losartan-d4 Related Antibodies

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Description

Losartan-d4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

IC50 & Target

AT1 Receptor

 

Molecular Weight

426.94

Formula

C22H19D4ClN6O
CAS No.
Unlabeled CAS

114798-26-4
Appearance

Solid

Color

White to off-white

SMILES

OCC1=C(Cl)N=C(CCCC)N1CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NNN=N4)C([2H])=C2[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 42.69 mg/mL (99.99 mM)

DMSO : ≥ 42.69 mg/mL (99.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3422 mL 11.7112 mL 23.4225 mL
5 mM 0.4684 mL 2.3422 mL 4.6845 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.3422 mL 11.7112 mL 23.4225 mL 58.5562 mL
5 mM 0.4684 mL 2.3422 mL 4.6845 mL 11.7112 mL
10 mM 0.2342 mL 1.1711 mL 2.3422 mL 5.8556 mL
15 mM 0.1561 mL 0.7807 mL 1.5615 mL 3.9037 mL
20 mM 0.1171 mL 0.5856 mL 1.1711 mL 2.9278 mL
25 mM 0.0937 mL 0.4684 mL 0.9369 mL 2.3422 mL
30 mM 0.0781 mL 0.3904 mL 0.7807 mL 1.9519 mL
40 mM 0.0586 mL 0.2928 mL 0.5856 mL 1.4639 mL
50 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1711 mL
60 mM 0.0390 mL 0.1952 mL 0.3904 mL 0.9759 mL
80 mM 0.0293 mL 0.1464 mL 0.2928 mL 0.7320 mL
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Losartan-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Losartan-d41030937-27-9DuP-753 d4Angiotensin ReceptorInhibitorinhibitorinhibit

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