2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Losartan-d4 (carboxylic acid)

Losartan-d4 (carboxylic acid)  (Synonyms: E-3174 d4; EXP-3174 d4)

Cat. No.: HY-12765S Purity: 98.17%
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Losartan-d4 (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

For research use only. We do not sell to patients.

Losartan-d<sub>4</sub> (carboxylic acid) Chemical Structure

Losartan-d4 (carboxylic acid) Chemical Structure

CAS No. : 1246820-62-1

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1 mg USD 210 In-stock
5 mg USD 810 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Losartan-d4 (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.

Molecular Weight

440.92

Formula

C22H17D4ClN6O2
CAS No.
Unlabeled CAS

124750-92-1
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=C(C(O)=O)N(CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NN=NN4)C([2H])=C2[2H])C(CCCC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (567.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 250 mg/mL (567.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2680 mL 11.3399 mL 22.6798 mL
5 mM 0.4536 mL 2.2680 mL 4.5360 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.2680 mL 11.3399 mL 22.6799 mL 56.6996 mL
5 mM 0.4536 mL 2.2680 mL 4.5360 mL 11.3399 mL
10 mM 0.2268 mL 1.1340 mL 2.2680 mL 5.6700 mL
15 mM 0.1512 mL 0.7560 mL 1.5120 mL 3.7800 mL
20 mM 0.1134 mL 0.5670 mL 1.1340 mL 2.8350 mL
25 mM 0.0907 mL 0.4536 mL 0.9072 mL 2.2680 mL
30 mM 0.0756 mL 0.3780 mL 0.7560 mL 1.8900 mL
40 mM 0.0567 mL 0.2835 mL 0.5670 mL 1.4175 mL
50 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1340 mL
60 mM 0.0378 mL 0.1890 mL 0.3780 mL 0.9450 mL
80 mM 0.0283 mL 0.1417 mL 0.2835 mL 0.7087 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
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Losartan-d4 (carboxylic acid) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Losartan-d4 (carboxylic acid)1246820-62-1E-3174 d4EXP-3174 d4Angiotensin ReceptorInhibitorinhibitorinhibit

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