2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species Endogenous Metabolite
  4. Lycopene

Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.

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Lycopene Chemical Structure

Lycopene Chemical Structure

CAS No. : 502-65-8

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Based on 9 publication(s) in Google Scholar

Other Forms of Lycopene:

Lycopene Related Antibodies

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Description

Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Sufficient uptake of lycopene from the diet is necessary to benefit from its health promoting effects, since humans are unable to synthesise lycopene de novo. Lycopene significantly inhibits prostate and breast cancer cell growth at physiologically relevant concentrations of 1.25 μM and also causes a 30-40 % reduction in inhibitor of kappa B phosphorylation in the cells[1].
Increased intake of lycopene, a major carotenoid in tomatoes, consumed as the all-trans-isomer attenuates alcohol induced apoptosis in 2E1 cells and reduces risk of prostate, lung and digestive cancers. Lycopene plays a role in the protection against photooxidative processes by acting as singlet molecular oxygen and peroxyl radicals scavengers and can interact synergistically with other antioxidants[2].
Lycopene as a carotenoid can react with types of reactive oxygen species (ROS) in three different mechanisms: I) by electron-transfer, II) by hydrogen atom transfer or III) by adduct formation. Lycopene is able to deactivate singlet oxygen mainly by physical quenching[3].
Lycopene decreases ROS production in SK-Hep-1 cells through inhibition of NADPH oxidase, brought about in the PKC pathway[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lycopene Related Antibodies
In Vivo

Lycopene is the most predominant carotenoid in human plasma and has a half life of about 2-3 days[2].
Lycopene or processed tomatoes may lead to a reduction of intima-media thickness in vessel walls[3].
Lycopene exerts protective effects against ATZ-induced toxicity in rat adrenal cortex. These effects may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway[4].
Lycopene improves hepatotoxicity acting as an antioxidant, reduces GSSG and regulates tGSH and CAT levels, reduces oxidative damage[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

536.87

Formula

C40H56
CAS No.
Appearance

Solid

Color

Purple to red

SMILES

C/C(C)=C\CC/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(/C=C/C=C(C)/C=C/C=C(CC/C=C(C)\C)\C)C
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

THF : 5 mg/mL (9.31 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6265 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.11%

COA (237 KB) HNMR (271 KB) RP-HPLC (256 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

PC3 cells and MDA-MB-231 cells are treated with (0, 0.5, 1.25, 2.5 and 5 μM) lycopene for 48 h. Cell survival/growth is measured using the colorimetric MTS assay method. MTS-PMS complex (20 μL) is added to each well. The catalytic activity of viable cells results in formazan dye production, which is then quantified. Cells are incubated with the dye for 1 h, followed by absorbance reading at 492 nm on a spectrophotometer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

Rats: Lycopene is dissolved in corn oil. 35 adult male albino rats are randomized into five equal groups: untreated control, vehicle control (receives 0.5 mL corn oil/day), lycopene (10 mg/kg b.w./day), ATZ (dissolved in 0.5 mL corn oil 300 mg/kg b.w./day), and ATZ + lycopene. All treatments are given by oral gavage for 4 weeks[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
THF 1 mM 1.8626 mL 9.3132 mL 18.6265 mL 46.5662 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL 9.3132 mL
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Lycopene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lycopene502-65-8Reactive Oxygen SpeciesEndogenous MetaboliteInhibitorinhibitorinhibit

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