2. Anti-infection
  3. RSV
  4. VP-14637

MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.

For research use only. We do not sell to patients.

VP-14637 Chemical Structure

VP-14637 Chemical Structure

CAS No. : 235106-62-4

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Based on 1 publication(s) in Google Scholar

VP-14637 Related Antibodies

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Description

MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL.

IC50 & Target

IC50: 1.42 ng/mL (RSV)[1]
In Vitro

MDT‐637 has broad in vitro antiviral activity on clinical strains of different RSV genotypes and clades. MDT-637 inhibits three laboratory strains (RSV-A Long, RSV-A2, and RSV-9320) and four clinical strains (RSV-Memphis-37, RSV-LAP0824, and RSV-HAN1135) with IC50s range from 0.36 to 3.4 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VP-14637 Related Antibodies
Molecular Weight

510.51

Formula

C25H22N10O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C(C2=CC=C(O)C=C2)C3=C(O)C=CC(/C=N/N4C(C)=NN=N4)=C3)C=C(/C=N/N5C(C)=NN=N5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (244.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9588 mL 9.7941 mL 19.5883 mL
5 mM 0.3918 mL 1.9588 mL 3.9177 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

The laboratory and clinical isolates of RSV and various concentrations (ranging from 0.1 μM to 31.6 pM) of MDT‐637 (or ribavirin) are added to the HEp-2 cell monolayers at the same time. After 72 hours of incubation at 37°C, the cells and supernatants are harvested. An aliquot is immediately serially diluted and used for plaque assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9588 mL 9.7941 mL 19.5883 mL 48.9706 mL
5 mM 0.3918 mL 1.9588 mL 3.9177 mL 9.7941 mL
10 mM 0.1959 mL 0.9794 mL 1.9588 mL 4.8971 mL
15 mM 0.1306 mL 0.6529 mL 1.3059 mL 3.2647 mL
20 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4485 mL
25 mM 0.0784 mL 0.3918 mL 0.7835 mL 1.9588 mL
30 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6324 mL
40 mM 0.0490 mL 0.2449 mL 0.4897 mL 1.2243 mL
50 mM 0.0392 mL 0.1959 mL 0.3918 mL 0.9794 mL
60 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8162 mL
80 mM 0.0245 mL 0.1224 mL 0.2449 mL 0.6121 mL
100 mM 0.0196 mL 0.0979 mL 0.1959 mL 0.4897 mL
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VP-14637 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VP-14637235106-62-4MDT-637VP14637VP 14637MDT637MDT 637RSVRespiratory syncytial virusInhibitorinhibitorinhibit

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