2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. MIV-247

MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

For research use only. We do not sell to patients.

MIV-247 Chemical Structure

MIV-247 Chemical Structure

CAS No. : 1352817-76-5

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Customer Review

Based on 2 publication(s) in Google Scholar

MIV-247 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MIV-247

WB

    MIV-247 purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2021 Feb;236(2):1309-1320.  [Abstract]

    Western blots showing protein expression of cleaved caspase‐8, cleaved caspase‐3, and cleaved PARP in the myocardium of sham and myocardial I/R mice.

    View All Cathepsin Isoform Specific Products:

    View All Isoforms
    Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.

    IC50 & Target

    cathepsin S

     

    In Vivo

    Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuates mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    391.39

    Formula

    C17H24F3N3O4
    CAS No.
    SMILES

    FC1(CCCC1)C[C@H](NC(C(F)(F)C)=O)C(NC2(CCC2)C(C(N)=O)=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    Animal Administration
    [1]

    Mice[1]

    MIV-247 is administered via oral gavage to Male C57BL/6 mice (20-30 g) at a dose volume of 5 ml/kg at doses up to 200 µmol/kg. In the PK studies, seven blood samples (20 µL) are drawn from the lateral saphenous vein of each mouse at 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 5 hours, and 7 hours postdose[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References
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    MIV-247 Related Classifications

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MIV-2471352817-76-5MIV247MIV 247CathepsinInhibitorinhibitorinhibit

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    Cat. No.:
    HY-112583
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