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Indacrinone  (Synonyms: MK-196; Indacrynic acid)

Cat. No.: HY-U00242 Purity: 99.89%
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Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.

For research use only. We do not sell to patients.

Indacrinone Chemical Structure

Indacrinone Chemical Structure

CAS No. : 56049-88-8

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5 mg USD 530 In-stock
10 mg USD 850 In-stock
25 mg USD 1700 In-stock
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Indacrinone Related Antibodies

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Description

Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.

In Vivo

As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

365.21

Formula

C18H14Cl2O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)COC1=CC2=C(C(C(C3=CC=CC=C3)(C)C2)=O)C(Cl)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (342.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7382 mL 13.6908 mL 27.3815 mL
5 mM 0.5476 mL 2.7382 mL 5.4763 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

Sixteen mice are administered Indacrinone-14C. Four mice, 2 male and 2 female, are dosed orally with 10 mg/kg of drug and four additional mice (2M, 2F) are given the drug i.v. via the tail vein. In similar fashion eight additional mice are dosed with 1 mg/kg Indacrinone-14C either orally or intravenously.The animals are housed in separate metabolism cages, 2 mice of same sex per cage.The animals are fasted overnight prior to drug administration. Urine and feces are collected for the 24-hour period post drug. Animals are allowed free access to water. Urine specimens are also obtained from mice which receive Indacrinone orally at doses of 10 and 20 mg/kg/day for 9 days. On day 9 the mice are dosed and placed in metabolism cages; two cages are used per sex per group. Urine is collected during the five-hour period post last dose. A total of nineteen mice are dosed with 10 mg/kg and 18 mice are dosed with 20 mg/kg of drug[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7382 mL 13.6908 mL 27.3815 mL 68.4538 mL
5 mM 0.5476 mL 2.7382 mL 5.4763 mL 13.6908 mL
10 mM 0.2738 mL 1.3691 mL 2.7382 mL 6.8454 mL
15 mM 0.1825 mL 0.9127 mL 1.8254 mL 4.5636 mL
20 mM 0.1369 mL 0.6845 mL 1.3691 mL 3.4227 mL
25 mM 0.1095 mL 0.5476 mL 1.0953 mL 2.7382 mL
30 mM 0.0913 mL 0.4564 mL 0.9127 mL 2.2818 mL
40 mM 0.0685 mL 0.3423 mL 0.6845 mL 1.7113 mL
50 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3691 mL
60 mM 0.0456 mL 0.2282 mL 0.4564 mL 1.1409 mL
80 mM 0.0342 mL 0.1711 mL 0.3423 mL 0.8557 mL
100 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
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Indacrinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indacrinone56049-88-8MK-196 Indacrynic acidMK196MK 196OthersInhibitorinhibitorinhibit

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