2. Epigenetics
  3. Histone Methyltransferase
  4. MM-589

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MM-589 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

MM-589 Chemical Structure

MM-589 Chemical Structure

CAS No. : 2097887-20-0

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Other Forms of MM-589:

MM-589 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

IC50 & Target

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]

Ki: <1 nM (WDR5)[1]
In Vitro

MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MM-589 Related Antibodies

Cell Viability Assay[1]

Cell Line: MV4-11 and MOLM-13 cells
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 4 days or 7 days
Result: Potently inhibited MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM.
Molecular Weight

572.70

Formula

C28H44N8O5
CAS No.
SMILES

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (174.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7461 mL 8.7306 mL 17.4611 mL
5 mM 0.3492 mL 1.7461 mL 3.4922 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7461 mL 8.7306 mL 17.4611 mL 43.6529 mL
5 mM 0.3492 mL 1.7461 mL 3.4922 mL 8.7306 mL
10 mM 0.1746 mL 0.8731 mL 1.7461 mL 4.3653 mL
15 mM 0.1164 mL 0.5820 mL 1.1641 mL 2.9102 mL
20 mM 0.0873 mL 0.4365 mL 0.8731 mL 2.1826 mL
25 mM 0.0698 mL 0.3492 mL 0.6984 mL 1.7461 mL
30 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4551 mL
40 mM 0.0437 mL 0.2183 mL 0.4365 mL 1.0913 mL
50 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8731 mL
60 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
80 mM 0.0218 mL 0.1091 mL 0.2183 mL 0.5457 mL
100 mM 0.0175 mL 0.0873 mL 0.1746 mL 0.4365 mL
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MM-589 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-5892097887-20-0MM589MM 589Histone MethyltransferaseInhibitorinhibitorinhibit

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