2. Epigenetics
  3. Histone Methyltransferase
  4. MM-589 (racemic mixture ) (TFA)

MM-589 (racemic mixture ) (TFA) 

Cat. No.: HY-100869B Purity: 99.83%
SDS COA Handling Instructions

Molarity Calculator

MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.

For research use only. We do not sell to patients.

MM-589 (racemic mixture ) (TFA) Chemical Structure

MM-589 (racemic mixture ) (TFA) Chemical Structure

Size Price Stock Quantity
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2500 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of MM-589 (racemic mixture ) (TFA):

MM-589 (racemic mixture ) (TFA) Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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  • Purity & Documentation

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  • Customer Review

Description

MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

IC50 & Target

IC50: 12.7 nM (H3K4 methyltransferase), 0.90 nM (WDR5)[1]
Molecular Weight

686.72

Formula

C30H45F3N8O7
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2.O=C(NCC[C@](NC(C(C)C)=O)(C)C3=O)[C@@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N3)=O)CC)=O)C4=CC=CC=C4.OC(C(F)(F)F)=O.[(7:3)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 40 mg/mL (58.25 mM; ultrasonic and adjust pH to 2 with 1M HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2810 mL 14.5620 mL
5 mM 0.2912 mL 1.4562 mL 2.9124 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.83%

SDS (251 KB)

COA (254 KB) HNMR (395 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4562 mL 7.2810 mL 14.5620 mL 36.4049 mL
5 mM 0.2912 mL 1.4562 mL 2.9124 mL 7.2810 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL 3.6405 mL
15 mM 0.0971 mL 0.4854 mL 0.9708 mL 2.4270 mL
20 mM 0.0728 mL 0.3640 mL 0.7281 mL 1.8202 mL
25 mM 0.0582 mL 0.2912 mL 0.5825 mL 1.4562 mL
30 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2135 mL
40 mM 0.0364 mL 0.1820 mL 0.3640 mL 0.9101 mL
50 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.7281 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MM-589 (racemic mixture ) (TFA) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-589 (racemic mixture ) (TFA)Histone MethyltransferaseCancerleukemiaMLLWDR5H3K4Inhibitorinhibitorinhibit

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