2. Anti-infection
  3. Bacterial
  4. MUT056399

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.

For research use only. We do not sell to patients.

MUT056399 Chemical Structure

MUT056399 Chemical Structure

CAS No. : 1269055-85-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

MUT056399 Related Antibodies

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  • Purity & Documentation

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Description

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli with 50% inhibitory concentration IC50s of 12 nM and 58 nM, respectively.

IC50 & Target

IC50 value: 12 nM (for S. aureus), 58 nM (for E. coli)[1]
In Vitro

MUT056399 (Fab-001) is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli. MUT056399 is very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC90s between 0.03 and 0.12 μg/ml. MUT056399 is also active against coagulase-negative staphylococci, with MIC90s between 0.12 and 4 μg/ml. MUT056399 is very active against the 118 S. aureus strains tested, including MSSA and MRSA isolates and linezolid-resistant and multidrug-resistant strains, with MIC90s between ≤0.03 and 0.12 μg/ml.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MUT056399 Related Antibodies
In Vivo

MUT056399 (Fab-001), administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day). In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

293.27

Formula

C15H13F2NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCC1=CC(O)=C(OC2=CC=C(C(N)=O)C=C2F)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (105.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4098 mL 17.0491 mL 34.0983 mL
5 mM 0.6820 mL 3.4098 mL 6.8197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

COA (246 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4098 mL 17.0491 mL 34.0983 mL 85.2457 mL
5 mM 0.6820 mL 3.4098 mL 6.8197 mL 17.0491 mL
10 mM 0.3410 mL 1.7049 mL 3.4098 mL 8.5246 mL
15 mM 0.2273 mL 1.1366 mL 2.2732 mL 5.6830 mL
20 mM 0.1705 mL 0.8525 mL 1.7049 mL 4.2623 mL
25 mM 0.1364 mL 0.6820 mL 1.3639 mL 3.4098 mL
30 mM 0.1137 mL 0.5683 mL 1.1366 mL 2.8415 mL
40 mM 0.0852 mL 0.4262 mL 0.8525 mL 2.1311 mL
50 mM 0.0682 mL 0.3410 mL 0.6820 mL 1.7049 mL
60 mM 0.0568 mL 0.2842 mL 0.5683 mL 1.4208 mL
80 mM 0.0426 mL 0.2131 mL 0.4262 mL 1.0656 mL
100 mM 0.0341 mL 0.1705 mL 0.3410 mL 0.8525 mL
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MUT056399 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MUT0563991269055-85-7Fab-001MUT 056399MUT-056399Fab001Fab 001BacterialInhibitorinhibitorinhibit

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