2. Immunology/Inflammation
  3. CD73
  4. MethADP

MethADP  (Synonyms: Adenosine 5'-(α,β-methylene)diphosphate)

Cat. No.: HY-112502 Purity: ≥99.0%
SDS COA Handling Instructions

Molarity Calculator

MethADP is a specific CD73 inhibitor.

For research use only. We do not sell to patients.

MethADP Chemical Structure

MethADP Chemical Structure

CAS No. : 3768-14-7

Size Price Stock Quantity
1 mg USD 250 In-stock
5 mg USD 600 In-stock
10 mg   Get quote  
50 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MethADP:

MethADP Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MethADP is a specific CD73 inhibitor.

IC50 & Target

CD73[1].
In Vitro

MethADP (AMP-CP: 20 μM) causes a marked inhibition of adenosine formation (0.96±0.96 μM) compared to untreated controls (9.6±1.5 μM) in A498 and RT4 cells, and MethADP (100 μM) completely inhibits the adenosine formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MethADP Related Antibodies
Molecular Weight

425.23

Formula

C11H17N5O9P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O)[C@@H](COP(O)(CP(O)(O)=O)=O)O[C@H]1N2C=NC3=C2N=CN=C3N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (117.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3517 mL 11.7583 mL 23.5167 mL
5 mM 0.4703 mL 2.3517 mL 4.7033 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (394 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3517 mL 11.7583 mL 23.5167 mL 58.7917 mL
5 mM 0.4703 mL 2.3517 mL 4.7033 mL 11.7583 mL
10 mM 0.2352 mL 1.1758 mL 2.3517 mL 5.8792 mL
15 mM 0.1568 mL 0.7839 mL 1.5678 mL 3.9194 mL
20 mM 0.1176 mL 0.5879 mL 1.1758 mL 2.9396 mL
25 mM 0.0941 mL 0.4703 mL 0.9407 mL 2.3517 mL
30 mM 0.0784 mL 0.3919 mL 0.7839 mL 1.9597 mL
40 mM 0.0588 mL 0.2940 mL 0.5879 mL 1.4698 mL
50 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1758 mL
60 mM 0.0392 mL 0.1960 mL 0.3919 mL 0.9799 mL
80 mM 0.0294 mL 0.1470 mL 0.2940 mL 0.7349 mL
100 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5879 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MethADP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MethADP3768-14-7Adenosine 5'-(α,β-methylene)diphosphateCD73ecto-5′-nucleotidase, NT5EInhibitorinhibitorinhibit

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