Motilin (26-47), human, porcine

Name: Motilin (26-47), human, porcine
Brand: MedChemExpress
SKU: HY-P1037
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1037 Purity: 95.56%: FAQs
Data Sheet SDS COA Handling Instructions

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Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K_i and EC₅₀ of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Motilin (26-47), human, porcine Chemical Structure

CAS No. : 52906-92-0

Size	Price	Stock	Quantity
500 μg	USD 150	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1125	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K_i and EC₅₀ of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

IC₅₀ & Target

EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)^[1]
Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)^[1]

In Vitro

[Bpa¹,Ile¹³]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC₅₀ = 1.5 ± 0.4 nM)^[1]. Motilin binds with high affinity (IC₅₀ 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca²⁺ release, and increases cytosolic free Ca²⁺. Motilin induces a biphasic, concentration-dependent contraction (EC₅₀ = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2699.07

Formula

C₁₂₀H₁₈₈N₃₄O₃₅S

CAS No.

52906-92-0

Appearance

Solid

Color

White to off-white

Sequence

Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln

Sequence Shortening

FVPIFTYGELQRMQEKERNKGQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (18.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3705 mL	1.8525 mL	3.7050 mL
5 mM	0.0741 mL	0.3705 mL	0.7410 mL
10 mM	0.0370 mL	0.1852 mL	0.3705 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.56%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (241 KB) RP-HPLC (265 KB)

Handling Instructions (2659 KB)

References

[1]. Coulie B, et al. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem. 2001 Sep 21;276(38):35518-22. Epub 2001 Jul 18. [Content Brief]

[2]. Huang J, et al. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.3705 mL	1.8525 mL	3.7050 mL	9.2624 mL
	5 mM	0.0741 mL	0.3705 mL	0.7410 mL	1.8525 mL
	10 mM	0.0370 mL	0.1852 mL	0.3705 mL	0.9262 mL
	15 mM	0.0247 mL	0.1235 mL	0.2470 mL	0.6175 mL