2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Others
  3. Endogenous Metabolite iGluR Amino Acid Derivatives
  4. N,N-Dimethylglycine

N,N-Dimethylglycine  (Synonyms: Dimethylglycine; DMG; N-Methylsarcosine)

Cat. No.: HY-Y0511 Purity: ≥98.0%
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COA
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N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects.

For research use only. We do not sell to patients.

N,N-Dimethylglycine Chemical Structure

N,N-Dimethylglycine Chemical Structure

CAS No. : 1118-68-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
500 mg In-stock
5 g In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N,N-Dimethylglycine:

N,N-Dimethylglycine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N,N-Dimethylglycine

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Description

N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

N,N-Dimethylglycine (40 mg/mL) shows 88.40%, 98.90%, and 87.58% scavenging activities in the DPPH radical scavenging, ABTS+ radical scavenging, and H2O2 scavenging experiments[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N,N-Dimethylglycine Related Antibodies
In Vivo

N,N-Dimethylglycine (30-100 mg/kg; intraperitoneal injection; twice a day; 14 days) prevents the behavioral abnormalities and synaptic dysfunction induced by repeated drug exposure in male ICR mice[1].
N,N-Dimethylglycine (12 mg/0.3 mL sterile saline; gavage; single dose; subcutaneous injection 1 hour later) improves the histological morphology of the small intestine, enhances the antioxidant system, reduces oxidative damage, and increases the expression of antioxidant-related genes in male Kunming mice[2].
N,N-Dimethylglycine (12 mg/0.3 mL sterile saline; gavage; twice a day; 28 days) increases the body weight, the organ proportion of the liver and spleen, enhances the antioxidant capacity of serum and liver, and reduces the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as the malondialdehyde (MDA) content in serum and liver in male Kunming mice[3].
N,N-Dimethylglycine (12 mg/0.3 mL sterile saline; gavage; twice a day; 28 days) reduces the serum ALT and AST contents, the ROS level in hepatic mitochondria, and increases the antioxidant capacity of hepatic mitochondria and the mitochondrial membrane potential (MMP) level in male Kunming mice with Lipopolysaccharides (LPS) (HY-D1056)-induced oxidative stress model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (body weight 10-12 g, 3-week- old) + Repeated drug exposure (20 mg/kg, i.p., twice daily for 14 days)[1].
Dosage: 30 mg/kg, 100 mg/kg
Administration: Intraperitoneal injection, 20 min prior to each drug injection, twice a day, 14 days.
Result: Prevented the dtug-induced memory impairments in novel location recognition test (NLRT) and novel object recognition test (NORT), social withdrawal in reciprocal social interaction test, and enhanced head twitch response induced by serotonergic hallucinogen.
Animal Model: Male Kunming mice (weight 20-25 g, 40 days old) + Indomethacin injection (10 mg/kg BW)[2].
Dosage: 12 mg/0.3 mL sterile saline
Administration: Orally gavage; single dose; and then subcutaneous injection 1 hour later.
Result: Improved the histological morphology of the small intestine. Enhanced the antioxidant system, reduced oxidative damage, and increased the expression of antioxidant-related genes in the small intestine and its mitochondria compared with the indomethacin-treated group2.
Animal Model: Male Kunming mice (weight 20-25 g, 40 days old) + Lipopolysaccharides (LPS) injection (100 μg/kg body weight)[3].
Dosage: 12 mg/0.3 mL sterile saline
Administration: Orally gavage; twice a day; 28 days.
Result: Significantly decreased the serum ALT and AST content, ROS level, and expression of liver antioxidant gene MnSOD, Gpx1, Sirt1.
Significantly increased the hepatic mitochondrial antioxidant capacity (MnSOD, GSH, GPx, GR) and MMP level compared with the LPS-treated group.
Molecular Weight

103.12

Formula

C4H9NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN(C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (969.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.6974 mL 48.4872 mL 96.9744 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (969.74 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (244 KB) HNMR (231 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.6974 mL 48.4872 mL 96.9744 mL 242.4360 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL 48.4872 mL
10 mM 0.9697 mL 4.8487 mL 9.6974 mL 24.2436 mL
15 mM 0.6465 mL 3.2325 mL 6.4650 mL 16.1624 mL
20 mM 0.4849 mL 2.4244 mL 4.8487 mL 12.1218 mL
25 mM 0.3879 mL 1.9395 mL 3.8790 mL 9.6974 mL
30 mM 0.3232 mL 1.6162 mL 3.2325 mL 8.0812 mL
40 mM 0.2424 mL 1.2122 mL 2.4244 mL 6.0609 mL
50 mM 0.1939 mL 0.9697 mL 1.9395 mL 4.8487 mL
60 mM 0.1616 mL 0.8081 mL 1.6162 mL 4.0406 mL
80 mM 0.1212 mL 0.6061 mL 1.2122 mL 3.0304 mL
100 mM 0.0970 mL 0.4849 mL 0.9697 mL 2.4244 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N,N-Dimethylglycine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Dimethylglycine1118-68-9Dimethylglycine DMG N-MethylsarcosineEndogenous MetaboliteiGluRAmino Acid DerivativesIonotropic glutamate receptorsNMDAR Agonistnutrient supplementantioxidantmethyl donor,Inhibitorinhibitorinhibit

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