2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Naspm trihydrochloride

Naspm trihydrochloride  (Synonyms: 1-Naphthylacetyl spermine trihydrochloride)

Cat. No.: HY-12506A Purity: 99.47%
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Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

For research use only. We do not sell to patients.

Naspm trihydrochloride Chemical Structure

Naspm trihydrochloride Chemical Structure

CAS No. : 1049731-36-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 111 In-stock
Solution
10 mM * 1 mL in DMSO USD 111 In-stock
Solid
1 mg USD 31 In-stock
5 mg USD 106 In-stock
10 mg USD 143 In-stock
50 mg USD 506 In-stock
100 mg USD 891 In-stock
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Based on 8 publication(s) in Google Scholar

Other Forms of Naspm trihydrochloride:

Naspm trihydrochloride Related Antibodies

Top Publications Citing Use of Products

    Naspm trihydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol In Vitro. 2017 Oct;44:57-65.  [Abstract]

    A Transwell invasion assay of cells is used to measure invasiveness after treatment with L-glutamate, propofol, 1-Naphthyl acetyl spermine (NAS), or (R, S)-AMPA.

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    AMPA Receptor NMDA Receptor Kainate Receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

    In Vitro

    NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Naspm trihydrochloride Related Antibodies
    Molecular Weight

    479.91

    Formula

    C22H37Cl3N4O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (104.19 mM; Need ultrasonic)

    DMSO : 6.4 mg/mL (13.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0837 mL 10.4186 mL 20.8372 mL
    5 mM 0.4167 mL 2.0837 mL 4.1674 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    Concentration (final)

    C2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (208.37 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.47%

    COA (242 KB) HNMR (274 KB) LCMS (262 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.0837 mL 10.4186 mL 20.8372 mL 52.0931 mL
    5 mM 0.4167 mL 2.0837 mL 4.1674 mL 10.4186 mL
    10 mM 0.2084 mL 1.0419 mL 2.0837 mL 5.2093 mL
    H2O 15 mM 0.1389 mL 0.6946 mL 1.3891 mL 3.4729 mL
    20 mM 0.1042 mL 0.5209 mL 1.0419 mL 2.6047 mL
    25 mM 0.0833 mL 0.4167 mL 0.8335 mL 2.0837 mL
    30 mM 0.0695 mL 0.3473 mL 0.6946 mL 1.7364 mL
    40 mM 0.0521 mL 0.2605 mL 0.5209 mL 1.3023 mL
    50 mM 0.0417 mL 0.2084 mL 0.4167 mL 1.0419 mL
    60 mM 0.0347 mL 0.1736 mL 0.3473 mL 0.8682 mL
    80 mM 0.0260 mL 0.1302 mL 0.2605 mL 0.6512 mL
    100 mM 0.0208 mL 0.1042 mL 0.2084 mL 0.5209 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Naspm trihydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Naspm trihydrochloride1049731-36-31-Naphthylacetyl spermine trihydrochlorideiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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