Naspm trihydrochloride (Synonyms: 1-Naphthylacetyl spermine trihydrochloride)

Name: Naspm trihydrochloride
Brand: MedChemExpress
SKU: HY-12506A
Rating: 5.0 (8 reviews)

Cat. No.: HY-12506A Purity: 99.47%: FAQs
Data Sheet SDS COA Handling Instructions

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Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

For research use only. We do not sell to patients.

Naspm trihydrochloride Chemical Structure

CAS No. : 1049731-36-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 111	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 111	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 106	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 143	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 506	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 891	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Naspm trihydrochloride:

Naspm In-stock

7 Publications Citing Use of MCE Naspm trihydrochloride

•Toxicol In Vitro. 2017 Oct;44:57-65. [Abstract]

: Naspm trihydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol In Vitro. 2017 Oct;44:57-65. [Abstract]; A Transwell invasion assay of cells is used to measure invasiveness after treatment with L-glutamate, propofol, 1-Naphthyl acetyl spermine (NAS), or (R, S)-AMPA.

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Description

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

In Vitro

NASPM selectively suppresses the inwardly rectifying and Ca²⁺-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC₅₀ value of 0.33 µM. The blocking effect of NASPM on the Ca²⁺-permeable AMPA receptors is use and voltage-dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

479.91

Formula

C₂₂H₃₇Cl₃N₄O

CAS No.

1049731-36-3

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (104.19 mM; Need ultrasonic)

DMSO : 6.4 mg/mL (13.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0837 mL	10.4186 mL	20.8372 mL
5 mM	0.4167 mL	2.0837 mL	4.1674 mL
10 mM	0.2084 mL	1.0419 mL	2.0837 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (208.37 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.47%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (242 KB) HNMR (274 KB) LCMS (262 KB)

Handling Instructions (2659 KB)

References

[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.0837 mL	10.4186 mL	20.8372 mL	52.0931 mL
	5 mM	0.4167 mL	2.0837 mL	4.1674 mL	10.4186 mL
	10 mM	0.2084 mL	1.0419 mL	2.0837 mL	5.2093 mL
H₂O	15 mM	0.1389 mL	0.6946 mL	1.3891 mL	3.4729 mL
	20 mM	0.1042 mL	0.5209 mL	1.0419 mL	2.6047 mL
	25 mM	0.0833 mL	0.4167 mL	0.8335 mL	2.0837 mL
	30 mM	0.0695 mL	0.3473 mL	0.6946 mL	1.7364 mL
	40 mM	0.0521 mL	0.2605 mL	0.5209 mL	1.3023 mL
	50 mM	0.0417 mL	0.2084 mL	0.4167 mL	1.0419 mL
	60 mM	0.0347 mL	0.1736 mL	0.3473 mL	0.8682 mL
	80 mM	0.0260 mL	0.1302 mL	0.2605 mL	0.6512 mL
	100 mM	0.0208 mL	0.1042 mL	0.2084 mL	0.5209 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Naspm trihydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naspm trihydrochloride1049731-36-31-Naphthylacetyl spermine trihydrochlorideiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Naspm trihydrochloride (Synonyms: 1-Naphthylacetyl spermine trihydrochloride)

Customer Review

Other Forms of Naspm trihydrochloride:

Naspm trihydrochloride Related Antibodies

7 Publications Citing Use of MCE Naspm trihydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All iGluR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Naspm trihydrochloride Related Antibodies

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Dilution Calculator

Complete Stock Solution Preparation Table

Naspm trihydrochloride Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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