2. Natural Products
  3. Antibiotics
  4. Polyether Antibiotics

Polyether Antibiotics

Structural features of Polyether antibiotics include an exterior alkyl backbone that confers their lipophilic characteristics and an oxygen-rich internal cavity that can bind metal ions. They affect the targeted cells by changing the permeability of cellular membranes to cationic metal species that lead to changes in Na+/K+ gradient and an increase in the osmotic pressure inside the cell, causing swelling, vacuolization, and ultimately death of the bacterial cell. These antibiotics show a broad spectrum of bioactivity including antibacterial (both for drug-sensitive and drug-resistant bacteria), antifungal, anti-parasitic, antiviral and tumor cell cytotoxicity.

Polyether Antibiotics (6):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6687
    Calcimycin 52665-69-7 99.12%
    Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.
    Calcimycin
  • HY-100528
    Nanchangmycin 65101-87-3 99.67%
    Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
    Nanchangmycin
  • HY-100528A
    Dianemycin 35865-33-9 99.67%
    Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
    Dianemycin
  • HY-N6687A
    Calcimycin hemicalcium salt 59450-89-4
    Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.
    Calcimycin hemicalcium salt
  • HY-N7071
    Maduramicin 79356-08-4
    Maduramicin (Maduramycin) is isolated from the actinomycete Actinomadura rubra. Maduramicin is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection. Maduramicin induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.
    Maduramicin
  • HY-112225
    Narasin sodium 58331-17-2
    Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin sodium has antimicrobial and anticancer activity.
    Narasin sodium