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Nikethamide  (Synonyms: N,N-Diethylnicotinamide)

Cat. No.: HY-B1280 Purity: 99.87%
COA Handling Instructions

Molarity Calculator

Nikethamide (N,N-Diethylnicotinamide), one of the respiratory central stimulants, has the potential for respiratory failure research.

For research use only. We do not sell to patients.

Nikethamide Chemical Structure

Nikethamide Chemical Structure

CAS No. : 59-26-7

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Liquid
500 mg USD 50 In-stock
1 g USD 60 In-stock
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10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Nikethamide Related Antibodies

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Description

Nikethamide (N,N-Diethylnicotinamide), one of the respiratory central stimulants, has the potential for respiratory failure research[1][2][3][4].

In Vivo

Nikethamide (10-500 mg/kg, injection, once a day for 20 days)-stimulated respiration has a favorable effect on recovery after microwave irradiation and increases the survival rate in albino mice receiving whole-body microwave irradiation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino mice receiving whole-body microwave irradiation[2]
Dosage: 10-500 mg/kg
Administration: injection, once a day for 20 days
Result: Increased the survival rate among the mice with acute microwave lesions at doses of 50-100 mg/kg in albino mice receiving whole-body microwave irradiation.
Molecular Weight

178.23

Formula

C10H14N2O
CAS No.
Appearance

Liquid (Density: 1.06  g/cm3  )

Color

Colorless to light yellow

SMILES

O=C(C1=CC=CN=C1)N(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (280.54 mM)

DMSO : ≥ 1 mg/mL (5.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6107 mL 28.0536 mL 56.1073 mL
5 mM 1.1221 mL 5.6107 mL 11.2215 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (561.07 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

COA (247 KB) HNMR (232 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.6107 mL 28.0536 mL 56.1073 mL 140.2682 mL
5 mM 1.1221 mL 5.6107 mL 11.2215 mL 28.0536 mL
H2O 10 mM 0.5611 mL 2.8054 mL 5.6107 mL 14.0268 mL
15 mM 0.3740 mL 1.8702 mL 3.7405 mL 9.3512 mL
20 mM 0.2805 mL 1.4027 mL 2.8054 mL 7.0134 mL
25 mM 0.2244 mL 1.1221 mL 2.2443 mL 5.6107 mL
30 mM 0.1870 mL 0.9351 mL 1.8702 mL 4.6756 mL
40 mM 0.1403 mL 0.7013 mL 1.4027 mL 3.5067 mL
50 mM 0.1122 mL 0.5611 mL 1.1221 mL 2.8054 mL
60 mM 0.0935 mL 0.4676 mL 0.9351 mL 2.3378 mL
80 mM 0.0701 mL 0.3507 mL 0.7013 mL 1.7534 mL
100 mM 0.0561 mL 0.2805 mL 0.5611 mL 1.4027 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nikethamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nikethamide59-26-7N,N-DiethylnicotinamideOthersrespiratory central stimulantrespiratory failureInhibitorinhibitorinhibit

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