Olsalazine Disodium

Name: Olsalazine Disodium
Brand: MedChemExpress
SKU: HY-B0174
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0174 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Olsalazine Disodium is an anti-inflammatory compound that works in inflammatory bowel disease and ulcerative colitis.

For research use only. We do not sell to patients.

Olsalazine Disodium Chemical Structure

CAS No. : 6054-98-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
5 g	USD 79	In-stock	Estimated Time of Arrival: December 31
10 g	USD 132	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Olsalazine Disodium:

Olsalazine-¹³C₆ Get quote
Olsalazine-d₃ Get quote
Olsalazine-d₃,¹⁵N Get quote
Olsalazine Get quote
Olsalazine Disodium (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Olsalazine Disodium is an anti-inflammatory compound that works in inflammatory bowel disease and ulcerative colitis.

Clinical Trial

Molecular Weight

346.20

Formula

C₁₄H₈N₂Na₂O₆

CAS No.

6054-98-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O[Na])C1=C(O)C=CC(/N=N/C2=CC(C(O[Na])=O)=C(O)C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (144.43 mM; Need ultrasonic)

DMSO : 20 mg/mL (57.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8885 mL	14.4425 mL	28.8850 mL
5 mM	0.5777 mL	2.8885 mL	5.7770 mL
10 mM	0.2889 mL	1.4443 mL	2.8885 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 15 mg/mL (43.33 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11. [Content Brief]

[2]. Gionchetti, P., et al., Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation. Dig Dis Sci, 1991. 36(2): p. 174-8. [Content Brief]

[3]. Brown, W.A., et al., 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci, 2000. 45(8): p. 1578-84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.8885 mL	14.4425 mL	28.8850 mL	72.2126 mL
	5 mM	0.5777 mL	2.8885 mL	5.7770 mL	14.4425 mL
	10 mM	0.2889 mL	1.4443 mL	2.8885 mL	7.2213 mL
	15 mM	0.1926 mL	0.9628 mL	1.9257 mL	4.8142 mL
	20 mM	0.1444 mL	0.7221 mL	1.4443 mL	3.6106 mL
	25 mM	0.1155 mL	0.5777 mL	1.1554 mL	2.8885 mL
	30 mM	0.0963 mL	0.4814 mL	0.9628 mL	2.4071 mL
	40 mM	0.0722 mL	0.3611 mL	0.7221 mL	1.8053 mL
	50 mM	0.0578 mL	0.2889 mL	0.5777 mL	1.4443 mL
H₂O	60 mM	0.0481 mL	0.2407 mL	0.4814 mL	1.2035 mL
	80 mM	0.0361 mL	0.1805 mL	0.3611 mL	0.9027 mL
	100 mM	0.0289 mL	0.1444 mL	0.2889 mL	0.7221 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.