Orexin B, human (Synonyms: Human orexin B)

Cat. No.: HY-P1339: FAQs
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Orexin B, human is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

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Orexin B, human Chemical Structure

CAS No. : 205640-91-1

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Description	Orexin B, human is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.
IC₅₀ & Target	Ki: 420 nM (OX1), 36 nM (OX2)^[1]
In Vitro	Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor^[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC₅₀ of 36 nM in the binding assay and an EC₅₀ of 60 nM in the [Ca²⁺]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC₅₀ in the competitive binding assay and the EC₅₀ in the [Ca²⁺]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Orexin B, human Related Antibodies
In Vivo	Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	2899.34
Formula	C₁₂₃H₂₁₂N₄₄O₃₅S
CAS No.	205640-91-1
Sequence	Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Sequence Shortening	RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [Content Brief] [2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Content Brief]

Animal Administration
^[2]

Rats^[2]

3 nM and 30 nM of synthetic human Orexin B is administered in a 5 mL bolus through a catheter placed in the left lateral ventricle of Male Wistar rats (180–200 g) in early light phase. Cumulative food consumption is observed and plotted over the period of 4 hr after injection^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [Content Brief]

[2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Content Brief]

Orexin B, human Related Classifications

Neurological Disease Endocrinology

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orexin B, human205640-91-1Human orexin BOrexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorInhibitorinhibitorinhibit

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