Macozinone (Synonyms: PBTZ169)

Name: Macozinone
Brand: MedChemExpress
SKU: HY-12903
Rating: 5.0 (4 reviews)

Cat. No.: HY-12903 Purity: 98.46%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect.

For research use only. We do not sell to patients.

Macozinone Chemical Structure

CAS No. : 1377239-83-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 99	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 99	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

4 Publications Citing Use of MCE Macozinone

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

DprE1^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	101.7 μM Compound: PBTZ169	Inhibition of human ERG transfected in HEK293 cells by whole-cell patch clamp method Inhibition of human ERG transfected in HEK293 cells by whole-cell patch clamp method	[PMID: 31408806]
HepG2	IC₅₀	18.98 μg/mL Compound: 2; PBTZ169	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30336450]
Vero	CC₅₀	> 125 μM Compound: PBTZ169	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 25754492]
Vero	IC₅₀	> 64 μg/mL Compound: 2; PBTZ169	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30336450]
Vero	CC₅₀	> 64 μg/mL Compound: PBTZ169	Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by MTT assay	[PMID: 33823392]
Vero	CC₅₀	1402.82 μM Compound: PBTZ169	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 28626525]
Vero	CC₅₀	31 μg/mL Compound: PBTZ169	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30692025]

In Vitro

Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

456.48

Formula

C₂₀H₂₃F₃N₄O₃S

CAS No.

1377239-83-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 6.4 mg/mL (14.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1907 mL	10.9534 mL	21.9068 mL
5 mM	0.4381 mL	2.1907 mL	4.3814 mL
10 mM	0.2191 mL	1.0953 mL	2.1907 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.46%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (248 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. [3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med. 2014 Mar;6(3):372-83. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1907 mL	10.9534 mL	21.9068 mL	54.7669 mL
	5 mM	0.4381 mL	2.1907 mL	4.3814 mL	10.9534 mL
	10 mM	0.2191 mL	1.0953 mL	2.1907 mL	5.4767 mL

Macozinone Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macozinone1377239-83-2PBTZ169PBTZ 169PBTZ-169BacterialAntibioticDprE1bactericidalbenzothiazinonecovalentantituberculosistuberculosisInhibitorinhibitorinhibit

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Macozinone (Synonyms: PBTZ169)

Customer Review

Macozinone Related Antibodies

4 Publications Citing Use of MCE Macozinone

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Macozinone Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Macozinone Related Classifications

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