PD 123319 ditrifluoroacetate

Name: PD 123319 ditrifluoroacetate
Brand: MedChemExpress
SKU: HY-10259A
Rating: 5.0 (10 reviews)

Cat. No.: HY-10259A Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

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PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC₅₀ of 34 nM.

For research use only. We do not sell to patients.

PD 123319 ditrifluoroacetate Chemical Structure

CAS No. : 136676-91-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 205	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 205	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 127	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 158	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 528	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of PD 123319 ditrifluoroacetate:

PD 123319 Get quote

9 Publications Citing Use of MCE PD 123319 ditrifluoroacetate

: PD 123319 ditrifluoroacetate purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062. [Abstract]; HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.

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AT1 Receptor AT2 Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC₅₀ of 34 nM.

IC₅₀ & Target

AT2 Receptor

In Vitro

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. ¹²⁵I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC₅₀ of 92.9 nM) for DuP-753. PD-123319 does not have any effect on ¹²⁵I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC₅₀ of 6.9 nM, and has a much lower affinity for DuP-753 (IC₅₀ around 10 microM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

736.66

Formula

C₃₅H₃₄F₆N₄O₇

CAS No.

136676-91-0

Appearance

Solid

Color

White to yellow

SMILES

FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 36 mg/mL (48.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3575 mL	6.7874 mL	13.5748 mL
5 mM	0.2715 mL	1.3575 mL	2.7150 mL
10 mM	0.1357 mL	0.6787 mL	1.3575 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (135.75 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (282 KB) SDS (393 KB)

COA (260 KB) LCMS (117 KB)

Handling Instructions (2659 KB)

References

[1]. Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60. [Content Brief]

[2]. Boulay G, et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41(4):809-15 [Content Brief]

[3]. Estrup TM, et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92. [Content Brief]

[4]. Brillante DG, et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6(2):102-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.3575 mL	6.7874 mL	13.5748 mL	33.9370 mL
	5 mM	0.2715 mL	1.3575 mL	2.7150 mL	6.7874 mL
	10 mM	0.1357 mL	0.6787 mL	1.3575 mL	3.3937 mL
	15 mM	0.0905 mL	0.4525 mL	0.9050 mL	2.2625 mL
	20 mM	0.0679 mL	0.3394 mL	0.6787 mL	1.6968 mL
	25 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3575 mL
	30 mM	0.0452 mL	0.2262 mL	0.4525 mL	1.1312 mL
	40 mM	0.0339 mL	0.1697 mL	0.3394 mL	0.8484 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.