2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BET degrader-3

PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

For research use only. We do not sell to patients.

PROTAC BET degrader-3 Chemical Structure

PROTAC BET degrader-3 Chemical Structure

CAS No. : 3031993-61-7

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5 mg USD 550 In-stock
10 mg USD 850 In-stock
25 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC BET degrader-3 Related Antibodies

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View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

IC50 & Target

BET[1]
Molecular Weight

1045.22

Formula

C53H64N12O9S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=NC7=C3C8=CC(OC)=C(C(C(C)=NO9)=C9C)C=C8N7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (95.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9567 mL 4.7837 mL 9.5674 mL
5 mM 0.1913 mL 0.9567 mL 1.9135 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9567 mL 4.7837 mL 9.5674 mL 23.9184 mL
5 mM 0.1913 mL 0.9567 mL 1.9135 mL 4.7837 mL
10 mM 0.0957 mL 0.4784 mL 0.9567 mL 2.3918 mL
15 mM 0.0638 mL 0.3189 mL 0.6378 mL 1.5946 mL
20 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1959 mL
25 mM 0.0383 mL 0.1913 mL 0.3827 mL 0.9567 mL
30 mM 0.0319 mL 0.1595 mL 0.3189 mL 0.7973 mL
40 mM 0.0239 mL 0.1196 mL 0.2392 mL 0.5980 mL
50 mM 0.0191 mL 0.0957 mL 0.1913 mL 0.4784 mL
60 mM 0.0159 mL 0.0797 mL 0.1595 mL 0.3986 mL
80 mM 0.0120 mL 0.0598 mL 0.1196 mL 0.2990 mL
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PROTAC BET degrader-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BET degrader-33031993-61-7PROTAC BET degrader3PROTAC BET degrader 3PROTACsEpigenetic Reader DomainInhibitorinhibitorinhibit

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