PROTAC BET degrader-3

Cat. No.: HY-114229 Purity: 98.03%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

For research use only. We do not sell to patients.

PROTAC BET degrader-3 Chemical Structure

CAS No. : 3031993-61-7

Size	Price	Stock	Quantity
1 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE PROTAC BET degrader-3

•Structure. 2024 Sep 28:S0969-2126(24)00385-X. [Abstract]

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
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Description

PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

IC₅₀ & Target

BET^[1]

Molecular Weight

1045.22

Formula

C₅₃H₆₄N₁₂O₉S

CAS No.

3031993-61-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=NC7=C3C8=CC(OC)=C(C(C(C)=NO9)=C9C)C=C8N7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (95.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9567 mL	4.7837 mL	9.5674 mL
5 mM	0.1913 mL	0.9567 mL	1.9135 mL
10 mM	0.0957 mL	0.4784 mL	0.9567 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (241 KB) SDS (251 KB)

COA (246 KB) LCMS (270 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9567 mL	4.7837 mL	9.5674 mL	23.9184 mL
	5 mM	0.1913 mL	0.9567 mL	1.9135 mL	4.7837 mL
	10 mM	0.0957 mL	0.4784 mL	0.9567 mL	2.3918 mL
	15 mM	0.0638 mL	0.3189 mL	0.6378 mL	1.5946 mL
	20 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1959 mL
	25 mM	0.0383 mL	0.1913 mL	0.3827 mL	0.9567 mL
	30 mM	0.0319 mL	0.1595 mL	0.3189 mL	0.7973 mL
	40 mM	0.0239 mL	0.1196 mL	0.2392 mL	0.5980 mL
	50 mM	0.0191 mL	0.0957 mL	0.1913 mL	0.4784 mL
	60 mM	0.0159 mL	0.0797 mL	0.1595 mL	0.3986 mL
	80 mM	0.0120 mL	0.0598 mL	0.1196 mL	0.2990 mL