Potassium clavulanate cellulose  (Synonyms: Potassium clavulanate:cellulose (1:1))

Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Clavulanate potassium is a form of Clavulanic acid. Clavulanate potassium fights bacteria that resistant to penicillins and other antibiotics. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin^[1][2].

Clavulanate potassium (2 μg/mL) is susceptive to β-lactamase-positive and β-lactamase-negative Bacteroides spp. and Fusobacterium spp. with the combination of amoxicillin (4 μg/mL) and ticarcillin (64 μg/mL)^[1].
Clavulanate potassium (16 μg/mL) inhibits B. intermedius, B. bivius, B. disiens, B. oris, B. buccae, B. buccalis and B. loeschei with MIC₅₀ values of 8 μg/mL^[1].
Clavulanate potassium (16 μg/mL) inhibits B. melaninogenicus, B. oralis and F. varium with MIC₅₀ values of 16 μg/mL^[1].
Clavulanate potassium (2 μg/mL) raises amoxicillin susceptibility rates for β-lactamase-positive Bacteroides species and fusobacteria from 41.3 to 90.8% and from 64.2 to 88.7%, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clavulanate potassium (125 mg; 20 d) protects 75% of mice with experimental pneumonitis compared with no survivors in the control group^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

238.26 (Potassiumclavulanate)

C₈H₉NO₅K .(C₆H₁₀O₅)n

Solid

White to off-white

O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](C)[C@@H](CO)O2)[C@@H](CO)O[C@@H](OC)[C@@H]1O.O=C([C@@H](/C(O[C@]3([H])C4)=C/CO)N3C4=O)O[K].[n]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Appelbaum PC, et al. Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50.  [Content Brief]

  [2]. Beale AS, et al. Comparative activities of amoxycillin, amoxycillin/clavulanic acid and tetracycline against Chlamydia trachomatis in cell culture and in an experimental mouse pneumonitis. J Antimicrob Chemother. 1991 May;27(5):627-38.  [Content Brief]