Protease-Activated Receptor-4

Name: Protease-Activated Receptor-4
Brand: MedChemExpress
SKU: HY-P0297
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0297 Purity: 95.35%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Protease-Activated Receptor-4 Chemical Structure

CAS No. : 245443-52-1

Size	Price	Stock	Quantity
5 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 168	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 372	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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View All Protease Activated Receptor (PAR) Isoform Specific Products:

View All Isoforms

PAR1 PAR2 PAR4

Biological Activity
Purity & Documentation
References
Customer Review

Description

Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

IC₅₀ & Target

PAR4

In Vitro

GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold^[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

666.77

Formula

C₃₃H₄₆N₈O₇

CAS No.

245443-52-1

Appearance

Solid

Color

White to off-white

Sequence

Gly-Tyr-Pro-Gly-Lys-Phe-NH2

Sequence Shortening

GYPGKF-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (74.99 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4998 mL	7.4988 mL	14.9977 mL
5 mM	0.3000 mL	1.4998 mL	2.9995 mL
10 mM	0.1500 mL	0.7499 mL	1.4998 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (149.98 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 95.35%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (258 KB) RP-HPLC (257 KB)

Handling Instructions (2659 KB)

References

[1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print] [Content Brief]

[2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4998 mL	7.4988 mL	14.9977 mL	37.4942 mL
	5 mM	0.3000 mL	1.4998 mL	2.9995 mL	7.4988 mL
	10 mM	0.1500 mL	0.7499 mL	1.4998 mL	3.7494 mL
	15 mM	0.1000 mL	0.4999 mL	0.9998 mL	2.4996 mL
	20 mM	0.0750 mL	0.3749 mL	0.7499 mL	1.8747 mL
	25 mM	0.0600 mL	0.3000 mL	0.5999 mL	1.4998 mL
	30 mM	0.0500 mL	0.2500 mL	0.4999 mL	1.2498 mL
	40 mM	0.0375 mL	0.1875 mL	0.3749 mL	0.9374 mL
	50 mM	0.0300 mL	0.1500 mL	0.3000 mL	0.7499 mL
	60 mM	0.0250 mL	0.1250 mL	0.2500 mL	0.6249 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.