PAR2

PAR2 Related Products (25):

By Type:	Selective (5)
By Effects:	Inhibitors (5) Agonists (10) Antagonists (8) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-129047

Trypsin	Activator
Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation.

HY-112558

AZ3451	Antagonist	99.84%
AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC₅₀ of 23 nM.

HY-P1314

2-Furoyl-LIGRLO-amide	Agonist	99.87%
2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD₂ value of 7.0..

HY-P0283

Protease-Activated Receptor-2, amide	Agonist	98.73%
Protease-Activated Receptor-2, amide (SLIGKV-NH₂) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.

HY-120528A

GB-110 hydrochloride	Agonist	99.86%
GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca²⁺ release in HT29 cells with an EC₅₀ of 0.28 μM.

HY-111214

K-14585	Antagonist
K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide)-induced Ca²⁺ mobilisation in primary human keratinocytes.

HY-123617

AZ8838	Antagonist	98.87%
AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pK_i of 6.4 for hPAR2.

HY-120261

GB-88	Inhibitor	99.05%
GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca²⁺ release with an IC₅₀ of 2 μM.

HY-117793

I-191	Antagonist	99.14%
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist.

HY-124748A

ENMD-1068 hydrochloride	Antagonist	98.33%
ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis.

HY-P1260

FSLLRY-NH2	Inhibitor	98.52%
FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor.

HY-14350

AC-55541	Agonist	99.25%
AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC₅₀=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC₅₀ values of 5.9 and 6.6 in PI hydrolysis assays and Ca²⁺ mobilization assays and exhibits pronociceptive activity in vivo.

HY-P1260A

FSLLRY-NH2 TFA	Inhibitor	99.43%
FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor.

HY-138558

PAR-2-IN-1	Inhibitor	99.79%
PAR-2-IN-1 is a protease-activated receptor-2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anticancer effects.

HY-129047A

Trypsin (MS grade)	Activator
Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation.

HY-148016

I-287	Inhibitor	99.36%
I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gα_q and Gα_12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research.

HY-P1310

VKGILS-NH2	Agonist	99.81%
VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells.

HY-124061

GB83	Antagonist	99.80%
GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons.

HY-120528

GB-110	Agonist
GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 selectively induces PAR2-mediated intracellular Ca²⁺ release in HT29 cells with an EC₅₀ of 0.28 μM.

HY-138951

AY77	Agonist
AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC₅₀ of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca²⁺ release.

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