2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Quetiapine sulfoxide dihydrochloride

Quetiapine sulfoxide dihydrochloride  (Synonyms: Quetiapine S-oxide dihydrochloride)

Cat. No.: HY-G0014A Purity: 99.27%
COA Handling Instructions

Molarity Calculator

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.

For research use only. We do not sell to patients.

Quetiapine sulfoxide dihydrochloride Chemical Structure

Quetiapine sulfoxide dihydrochloride Chemical Structure

CAS No. : 329218-11-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 177 In-stock
Solution
10 mM * 1 mL in Water USD 177 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 170 In-stock
10 mg USD 270 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of Quetiapine sulfoxide dihydrochloride:

Quetiapine sulfoxide dihydrochloride Related Antibodies

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  • Purity & Documentation

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Description

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[2].

In Vivo

The Cmax value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUClast value is estimated for Quetiapine sulfoxide (1,286±458 ng•h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

472.43

Formula

C21H27Cl2N3O3S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

OCCOCCN(CC1)CCN1C2=NC(C=CC=C3)=C3S(C4=C2C=CC=C4)=O.Cl[H].Cl[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (529.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1167 mL 10.5836 mL 21.1672 mL
5 mM 0.4233 mL 2.1167 mL 4.2334 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (105.84 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.27%

COA (255 KB) RP-HPLC (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1167 mL 10.5836 mL 21.1672 mL 52.9179 mL
5 mM 0.4233 mL 2.1167 mL 4.2334 mL 10.5836 mL
10 mM 0.2117 mL 1.0584 mL 2.1167 mL 5.2918 mL
15 mM 0.1411 mL 0.7056 mL 1.4111 mL 3.5279 mL
20 mM 0.1058 mL 0.5292 mL 1.0584 mL 2.6459 mL
25 mM 0.0847 mL 0.4233 mL 0.8467 mL 2.1167 mL
30 mM 0.0706 mL 0.3528 mL 0.7056 mL 1.7639 mL
40 mM 0.0529 mL 0.2646 mL 0.5292 mL 1.3229 mL
50 mM 0.0423 mL 0.2117 mL 0.4233 mL 1.0584 mL
60 mM 0.0353 mL 0.1764 mL 0.3528 mL 0.8820 mL
80 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.6615 mL
100 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.5292 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Quetiapine sulfoxide dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quetiapine sulfoxide329218-11-3Quetiapine S-oxideDrug MetaboliteInhibitorinhibitorinhibit

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