2. Neuronal Signaling
  3. Legumain
  4. RR-11a

RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI).

For research use only. We do not sell to patients.

RR-11a Chemical Structure

RR-11a Chemical Structure

CAS No. : 1361390-56-8

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Other Forms of RR-11a:

RR-11a Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

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Description

RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI)[1][2][3].

IC50 & Target[2]

Legumain

31-55 nM (IC50)

In Vitro

Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RR-11a Related Antibodies
In Vivo

Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].
RR-11a (20 mg/kg; daily i.p. for 30 days) improves cardiac function, decreases cardiac rupture rate, and attenuates left chamber dilation and wall thinning post-AMI in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

560.51

Formula

C24H28N6O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](C)C(N[C@@H](C)C(NN(CC(N)=O)C(/C=C/C(ON1C(CCC1=O)=O)=O)=O)=O)=O)OCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (178.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7841 mL 8.9204 mL 17.8409 mL
5 mM 0.3568 mL 1.7841 mL 3.5682 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

Mice[1]

Mice bearing 4T1 orthothopic tumors of approximately 500 mm3 are injected once intravenously with RR-11a+ or RR-11a-nanoparticles labeled with rhodamine B. Alternatively, mice are injected intravenously 3 times at 48-hour intervals with RDZ-218, NP-DOX, free DOX, or saline. Twenty-four hours after the final treatment, animals are sacrificed and spleen, kidney, lungs, liver, heart and tumor are collected, frozen in OCT compound, immediately sectioned and imaged by fluorescence microscopy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7841 mL 8.9204 mL 17.8409 mL 44.6022 mL
5 mM 0.3568 mL 1.7841 mL 3.5682 mL 8.9204 mL
10 mM 0.1784 mL 0.8920 mL 1.7841 mL 4.4602 mL
15 mM 0.1189 mL 0.5947 mL 1.1894 mL 2.9735 mL
20 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2301 mL
25 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7841 mL
30 mM 0.0595 mL 0.2973 mL 0.5947 mL 1.4867 mL
40 mM 0.0446 mL 0.2230 mL 0.4460 mL 1.1151 mL
50 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.8920 mL
60 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7434 mL
80 mM 0.0223 mL 0.1115 mL 0.2230 mL 0.5575 mL
100 mM 0.0178 mL 0.0892 mL 0.1784 mL 0.4460 mL
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RR-11a Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RR-11a1361390-56-8LegumainAsparaginyl endopeptidaseδ-secretasemicecanceracute myocardial infarctioncardiac functionsyntheticInhibitorinhibitorinhibit

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