RWJ-445167 (Synonyms: 3DP-10017)

Cat. No.: HY-19373: Data Sheet Handling Instructions Technical Support

RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

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RWJ-445167 Chemical Structure

CAS No. : 226566-43-4

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Description	RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
IC₅₀ & Target	Ki: 4.0 nM (thrombin), 230 nM (factor Xa)^[1]
Molecular Weight	436.49
Formula	C₁₈H₂₄N₆O₅S
CAS No.	226566-43-4
SMILES	O=C(NCCONC(N)=N)CN1C(C)=CC=C(NS(=O)(C2=CC=CC(C)=C2)=O)C1=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. RWJ-445167, et al. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul;68(1):29-36. [Content Brief]

RWJ-445167 Related Classifications

Cardiovascular Disease

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Keywords:

RWJ-445167226566-43-43DP-10017RWJ445167RWJ 445167ThrombinFactor XaFxadualinhibitorantithromboticactivityInhibitorinhibit

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RWJ-445167 (Synonyms: 3DP-10017)

Biological Activity

Purity & Documentation

References

Customer Review

RWJ-445167 Related Classifications

Molarity Calculator

Dilution Calculator