Rabies Virus Glycoprotein

Name: Rabies Virus Glycoprotein
Brand: MedChemExpress
SKU: HY-P0285
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0285 Purity: 99.69%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Rabies Virus Glycoprotein Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Rabies Virus Glycoprotein:

Rabies Virus Glycoprotein TFA Get quote

1 Publications Citing Use of MCE Rabies Virus Glycoprotein

•Neurosci Bull. 2021 Mar 29. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

In Vitro

RVG peptide is successfully used to carry a variety of cargos into brain cells such as plasmids, siRNAs, proteins, and nanoparticles^[1]. RVG29 can govern the interaction of viral particles with at least three known receptors, including neural cell adhesion molecule (NCAM), the p75 neurotrophin receptor (P75NTR), and nicotinic acetylcholine receptors (NAChRs). The RVG29 peptide enhances the brain-specific function of a range of systemically delivered agents, particularly nucleic acids^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3266.70

Formula

C₁₄₁H₂₁₇N₄₃O₄₃S₂

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Thr-Ile-Trp-Met-Pro-Glu-Asn-Pro-Arg-Pro-Gly-Thr-Pro-Cys-Asp-Ile-Phe-Thr-Asn-Ser-Arg-Gly-Lys-Arg-Ala-Ser-Asn-Gly

Sequence Shortening

YTIWMPENPRPGTPCDIFTNSRGKRASNG

Structure Classification

Others

Initial Source

Microorganisms

Rabies Virus Glycoprotein

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (30.61 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3061 mL	1.5306 mL	3.0612 mL
5 mM	0.0612 mL	0.3061 mL	0.6122 mL
10 mM	0.0306 mL	0.1531 mL	0.3061 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (241 KB) LCMS (91 KB) Elemental Analysis Report (100 KB)

Handling Instructions (2659 KB)

References

[1]. Zou Z, et al. Cre Fused with RVG Peptide Mediates Targeted Genome Editing in Mouse Brain Cells In Vivo. Int J Mol Sci. 2016 Dec 14;17(12). pii: E2104. [Content Brief]

[2]. Cook RL, et al. A critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system. J Control Release. 2015 Dec 28;220(Pt A):89-97. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3061 mL	1.5306 mL	3.0612 mL	7.6530 mL
	5 mM	0.0612 mL	0.3061 mL	0.6122 mL	1.5306 mL
	10 mM	0.0306 mL	0.1531 mL	0.3061 mL	0.7653 mL
	15 mM	0.0204 mL	0.1020 mL	0.2041 mL	0.5102 mL
	20 mM	0.0153 mL	0.0765 mL	0.1531 mL	0.3826 mL
	25 mM	0.0122 mL	0.0612 mL	0.1224 mL	0.3061 mL
	30 mM	0.0102 mL	0.0510 mL	0.1020 mL	0.2551 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.