2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15234S
    Fluticasone furoate-d3
    Fluticasone furoate-d3 is deuterium labeled Fluticasone furoate. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment[1][2].
    Fluticasone furoate-d3
  • HY-152535
    ATV041 2935937-67-8
    ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner.
    ATV041
  • HY-152576
    CB2R agonist 1 1817633-49-0
    CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role.
    CB2R agonist 1
  • HY-152954
    DRAK1/2-IN-1 1629227-34-4
    DRAK1/2-IN-1 (compound 10e) is an active dual DRAK1 and DRAK2 inhibitor with Kd values of 1 μM and 6 μM, respectively.
    DRAK1/2-IN-1
  • HY-153002
    p38α inhibitor 3 260428-69-1 99.82%
    p38α inhibitor 3 (Comp G7) is a p38α inhibitor that blocks the effectiveness of myoblast differentiation.
    p38α inhibitor 3
  • HY-153070
    TLR7 agonist 5 2380231-67-2
    TLR7 agonist 5 (compound IIb-11) is an TLR7 agonist with an EC50 value of ~4 nM.
    TLR7 agonist 5
  • HY-153072
    TLR7 agonist 7 2380231-77-4
    TLR7 agonist 7 (compound IIb-26) is an TLR7 agonist with an EC50 value of ~4 nM.
    TLR7 agonist 7
  • HY-153073
    TLR7 agonist 8 2380231-81-0
    TLR7 agonist 8 (compound IIb-34) is an TLR7 agonist with an EC50 value of ~4 nM.
    TLR7 agonist 8
  • HY-153085
    CD19 CAR circRNA
    CD19 CAR circRNA will express CD19 car protein, and can be used in chimeric antigen receptor T cell immunotherapy (CAR-CD19). The CD19 car is a chimeric antigen receptor. Among them, CD19 is a CD molecule expressed by B cells (i.e. leukocyte differentiation antigen), an important membrane antigen involved in B cell proliferation, differentiation, activation and antibody production, and can also promote BCR signal transduction.
    CD19 CAR circRNA
  • HY-153103
    LRRK2/NUAK1/TYK2-IN-1 2629192-96-5
    LRRK2/NUAK1/TYK2-IN-1 (conpound 226) shows inhibitory activity toward LRRK2 (Wt), LRRK2 (G2019), TYK2 and NUAK1, with IC50 values lower than 10 nM. LRRK2/NUAK1/TYK2-IN-1 can be used for autoimmune disease research.
    LRRK2/NUAK1/TYK2-IN-1
  • HY-15315S
    Baricitinib-d5 1564241-79-7
    Baricitinib-d5 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
    Baricitinib-d5
  • HY-15321A
    Etoricoxib hydrochloride 202409-40-3
    Etoricoxib hydrochloride (MK-0663 hydrochloride) is a synthetic nonsteroidal anti-inflammatory drug with cyclooxygenase-2 inhibitory activity. Etoricoxib hydrochloride can inhibit the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation and pain. Etoricoxib hydrochloride is used to inhibit osteoarthritis and has anti-inflammatory and bone remodeling effects. The formulation of etoricoxib hydrochloride is prepared by emulsion solvent evaporation technology and exhibits good cell compatibility and enhanced alkaline phosphatase activity.
    Etoricoxib hydrochloride
  • HY-15321R
    Etoricoxib (Standard) 202409-33-4
    Etoricoxib (Standard) is the analytical standard of Etoricoxib. This product is intended for research and analytical applications. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
    Etoricoxib (Standard)
  • HY-153234
    CD19 car circRNA-LNP
    CD19 car circRNA-LNP is a lipid nanoparticle (LNP) containing CD19 car circRNA, suitable for detection of RNA delivery, translation efficiency, cell viability, etc. CD19 car circRNA can be used in chimeric antigen receptor T cell immunotherapy (CAR-CD19). The CD19 car is a chimeric antigen receptor. Among them, CD19 is a CD molecule expressed by B cells (i.e. leukocyte differentiation antigen), an important membrane antigen involved in B cell proliferation, differentiation, activation and antibody production, and can also promote BCR signal transduction.
    CD19 car circRNA-LNP
  • HY-153239
    Eltrombopag methyl ester 1246929-01-0
    Eltrombopag methyl ester is a derivative of Eltrombopag, which is a thrombopoietin (Tpo) receptor agonist, which can promote platelet production and is used in research related to specific types of thrombocytopenia.
    Eltrombopag methyl ester
  • HY-153240
    ACT-672125 1449367-94-5
    ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases.
    ACT-672125
  • HY-153242
    GSK217 2748687-92-3
    GSK217 is a potent, selective, and highly soluble bromo and extraterminal domain (BET) second bromodomain (BD2) inhibitor. GSK217 can be used for the research of oncology and immune inflammation research.
    GSK217
  • HY-153247
    GSK3839919A 2081127-77-5
    GSK3839919A is a potent and allosteric HIV-1integrase inhibitor.
    GSK3839919A
  • HY-153279
    5-LOX-IN-3 1875061-47-4
    5-LOX-IN-3 (Compound 14) is a 5-Lipoxygenase inhibitor (IC50: <1 μM). 5-LOX-IN-3 can be used for research of inflammatory diseases, cancer, stroke and Alzheimer's disease.
    5-LOX-IN-3
  • HY-153330
    TNF-α-IN-10 2247720-56-3
    TNF-α-IN-10 (compound 8a) is a IL-6 and TNF-α inhibitor. TNF-α-IN-10 shows anti-inflammatory activity.
    TNF-α-IN-10
Cat. No. Product Name / Synonyms Application Reactivity