Rimeporide hydrochloride (Synonyms: EMD-87580 hydrochloride)

Cat. No.: HY-19273A: FAQs
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Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

For research use only. We do not sell to patients.

Rimeporide hydrochloride Chemical Structure

CAS No. : 187870-95-7

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Other In-stock Forms of Rimeporide hydrochloride:

Rimeporide

Other Forms of Rimeporide hydrochloride:

Rimeporide In-stock

1 Publications Citing Use of MCE Rimeporide hydrochloride

•Preprints. 2023 Aug 14.

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Purity & Documentation
References
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Description

Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

IC₅₀ & Target

NHE1^[1]

In Vitro

Blocking NHE-1 activity has been shown to decrease intracellular Na⁺ and Ca²⁺ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

369.84

Formula

C₁₁H₁₆ClN₃O₅S₂

CAS No.

187870-95-7

SMILES

O=C(NC(N)=N)C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.

Rimeporide hydrochloride Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimeporide187870-95-7EMD-87580EMD87580EMD 87580Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen ExchangerInhibitorinhibitorinhibit

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