Rimeporide-¹⁵N₃ hydrochloride  (Synonyms: EMD-87580-¹⁵N₃ hydrochloride)

Rimeporide-¹⁵N₃ (hydrochloride) (EMD-87580-¹⁵N₃ (hydrochloride)) is ¹⁵N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

372.83

C₁₁H₁₆Cl¹⁵N₃O₅S₂

187870-95-7

O=S(C1=C(C=C(C(C([15NH]C([15NH2])=[15NH])=O)=C1)C)S(=O)(C)=O)(C)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.