2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. SAR7334

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

For research use only. We do not sell to patients.

SAR7334 Chemical Structure

SAR7334 Chemical Structure

CAS No. : 1333210-07-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 220 In-stock
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10 mM * 1 mL in DMSO USD 220 In-stock
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10 mg USD 320 In-stock
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Customer Review

Based on 17 publication(s) in Google Scholar

Other Forms of SAR7334:

SAR7334 Related Antibodies

Top Publications Citing Use of Products

    SAR7334 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015.  [Abstract]

    HK-2 cells are treated with different concentrations of SAR7334 for 12 h. Representative western blot images and the relative quantification of LC3-II are shown.

    View All TRP Channel Isoform Specific Products:

    View All Isoforms
    TRPC TRPM TRPV TRPA TRPML

    • Biological Activity

    • Purity & Documentation

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    Description

    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

    IC50 & Target

    IC50: 7.9 nM (TRPC6 currents)[3]
    In Vitro

    SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226 nM[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1]. SAR7334 (1 μM) has negligible effect on SOCE[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SAR7334 Related Antibodies
    In Vivo

    SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    367.87

    Formula

    C21H22ClN3O
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    N[C@@H](C1)CCCN1[C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(Cl)C=C(C#N)C=C4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 370 mg/mL (1005.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7184 mL 13.5918 mL 27.1835 mL
    5 mM 0.5437 mL 2.7184 mL 5.4367 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.82%

    COA (255 KB) LCMS (96 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7184 mL 13.5918 mL 27.1835 mL 67.9588 mL
    5 mM 0.5437 mL 2.7184 mL 5.4367 mL 13.5918 mL
    10 mM 0.2718 mL 1.3592 mL 2.7184 mL 6.7959 mL
    15 mM 0.1812 mL 0.9061 mL 1.8122 mL 4.5306 mL
    20 mM 0.1359 mL 0.6796 mL 1.3592 mL 3.3979 mL
    25 mM 0.1087 mL 0.5437 mL 1.0873 mL 2.7184 mL
    30 mM 0.0906 mL 0.4531 mL 0.9061 mL 2.2653 mL
    40 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6990 mL
    50 mM 0.0544 mL 0.2718 mL 0.5437 mL 1.3592 mL
    60 mM 0.0453 mL 0.2265 mL 0.4531 mL 1.1326 mL
    80 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8495 mL
    100 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6796 mL
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    SAR7334 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SAR73341333210-07-3SAR 7334SAR-7334TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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