SCH00013

Cat. No.: HY-100718: FAQs
Data Sheet SDS Handling Instructions

Molarity Calculator

SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.

For research use only. We do not sell to patients.

SCH00013 Chemical Structure

CAS No. : 217963-18-3

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 300	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO	USD 300	Ask For Quote & Lead Time
Solid
1 mg	USD 140	Ask For Quote & Lead Time
5 mg	USD 420	Ask For Quote & Lead Time
10 mg	USD 620	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Purity & Documentation
References
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Description

SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4. In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. [1] In vivo: The positive inotropic effects of 10 4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. [1] CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs. [2] SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate. [3]

Molecular Weight

324.38

Formula

C₁₈H₂₀N₄O₂

CAS No.

217963-18-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=C(C(O)CN2CC=C(C(CC3)=NNC3=O)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 32.5 mg/mL (100.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0828 mL	15.4140 mL	30.8280 mL
5 mM	0.6166 mL	3.0828 mL	6.1656 mL
10 mM	0.3083 mL	1.5414 mL	3.0828 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (270 KB) SDS (251 KB) Handling Instructions (2659 KB)

References

[1]. Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22. [Content Brief]

[2]. Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60. [Content Brief]

[3]. Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0828 mL	15.4140 mL	30.8280 mL	77.0701 mL
	5 mM	0.6166 mL	3.0828 mL	6.1656 mL	15.4140 mL
	10 mM	0.3083 mL	1.5414 mL	3.0828 mL	7.7070 mL
	15 mM	0.2055 mL	1.0276 mL	2.0552 mL	5.1380 mL
	20 mM	0.1541 mL	0.7707 mL	1.5414 mL	3.8535 mL
	25 mM	0.1233 mL	0.6166 mL	1.2331 mL	3.0828 mL
	30 mM	0.1028 mL	0.5138 mL	1.0276 mL	2.5690 mL
	40 mM	0.0771 mL	0.3854 mL	0.7707 mL	1.9268 mL
	50 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.5414 mL
	60 mM	0.0514 mL	0.2569 mL	0.5138 mL	1.2845 mL
	80 mM	0.0385 mL	0.1927 mL	0.3854 mL	0.9634 mL
	100 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.7707 mL

SCH00013 Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH00013217963-18-3SCH 00013SCH-00013OthersInhibitorinhibitorinhibit

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