SLLK, Control Peptide for TSP1 Inhibitor(TFA)

Name: SLLK, Control Peptide for TSP1 Inhibitor(TFA)
Brand: MedChemExpress
SKU: HY-P0301A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0301A Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SLLK, Control Peptide for TSP1 Inhibitor(TFA) Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 288	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 504	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of SLLK, Control Peptide for TSP1 Inhibitor(TFA):

SLLK, Control Peptide for TSP1 Inhibitor Get quote

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor.

In Vivo

Akita mice treated with 30 mg/kg LSKL have significantly increased nephrin expression, greater than twofold, compared with renal lysates from either saline controls or SLLK-treated mice^[1].TGF-β1 is significantly lower (0.10±0.01 pg/mL) in the plasma of mice receiving LSKL compared with that in plasma of mice receiving SLLK control peptide at day 42 (0.20±0.02 pg/mL; P=0.0001). MRNA expression is assessed in the suprarenal aortic lysates obtained from mice receiving SLLK and LSKL peptides^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

572.62

Formula

C₂₃H₄₃F₃N₆O₇

Appearance

Solid

Color

White to off-white

Sequence

Ser-Leu-Leu-Lys-NH2

Sequence Shortening

SLLK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (174.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7464 mL	8.7318 mL	17.4636 mL
5 mM	0.3493 mL	1.7464 mL	3.4927 mL
10 mM	0.1746 mL	0.8732 mL	1.7464 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (250 KB) HNMR (284 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Lu A, et al. Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am J Pathol. 2011 Jun;178(6):2573-86. [Content Brief]

[2]. Krishna SM, et al. A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):389-98. [Content Brief]

Animal Administration
^[1]

Mice^[1]
The i.p. injection of LSKL, SLLK, or saline began 2 weeks after uninephrectomy and continues thrice weekly for 15 weeks. For the low-dosage treatment regimen, each group of 20 mice receives 3 mg/kg body weight of peptide (LSKL or SLLK) per injection or saline (100 μL/10 g body weight per injection). For the high-dosage treatment regimen, Akita mice are given i.p. injections of LSKL or SLLK peptide at 30 mg/kg body weight per injection or saline (100 μL/10 g body weight per injection)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Lu A, et al. Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am J Pathol. 2011 Jun;178(6):2573-86. [Content Brief]

[2]. Krishna SM, et al. A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):389-98. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7464 mL	8.7318 mL	17.4636 mL	43.6590 mL
	5 mM	0.3493 mL	1.7464 mL	3.4927 mL	8.7318 mL
	10 mM	0.1746 mL	0.8732 mL	1.7464 mL	4.3659 mL
	15 mM	0.1164 mL	0.5821 mL	1.1642 mL	2.9106 mL
	20 mM	0.0873 mL	0.4366 mL	0.8732 mL	2.1829 mL
	25 mM	0.0699 mL	0.3493 mL	0.6985 mL	1.7464 mL
	30 mM	0.0582 mL	0.2911 mL	0.5821 mL	1.4553 mL
	40 mM	0.0437 mL	0.2183 mL	0.4366 mL	1.0915 mL
	50 mM	0.0349 mL	0.1746 mL	0.3493 mL	0.8732 mL
	60 mM	0.0291 mL	0.1455 mL	0.2911 mL	0.7276 mL
	80 mM	0.0218 mL	0.1091 mL	0.2183 mL	0.5457 mL
	100 mM	0.0175 mL	0.0873 mL	0.1746 mL	0.4366 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.