2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. SPDB

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).

For research use only. We do not sell to patients.

SPDB Chemical Structure

SPDB Chemical Structure

CAS No. : 115088-06-7

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Based on 1 publication(s) in Google Scholar

SPDB Related Antibodies

Top Publications Citing Use of Products

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  • References

  • Customer Review

Description

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs)[1].

IC50 & Target[1]

Disulfide Cleavable Linker

 

Cleavable Linker

 

Molecular Weight

326.39

Formula

C13H14N2O4S2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(CC1)N(OC(CCCSSC2=NC=CC=C2)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (306.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (306.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0638 mL 15.3191 mL 30.6382 mL
5 mM 0.6128 mL 3.0638 mL 6.1276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.82%

SDS (393 KB)

COA (248 KB) RP-HPLC (270 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 3.0638 mL 15.3191 mL 30.6382 mL 76.5955 mL
5 mM 0.6128 mL 3.0638 mL 6.1276 mL 15.3191 mL
10 mM 0.3064 mL 1.5319 mL 3.0638 mL 7.6595 mL
15 mM 0.2043 mL 1.0213 mL 2.0425 mL 5.1064 mL
20 mM 0.1532 mL 0.7660 mL 1.5319 mL 3.8298 mL
25 mM 0.1226 mL 0.6128 mL 1.2255 mL 3.0638 mL
30 mM 0.1021 mL 0.5106 mL 1.0213 mL 2.5532 mL
40 mM 0.0766 mL 0.3830 mL 0.7660 mL 1.9149 mL
50 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5319 mL
60 mM 0.0511 mL 0.2553 mL 0.5106 mL 1.2766 mL
80 mM 0.0383 mL 0.1915 mL 0.3830 mL 0.9574 mL
100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7660 mL
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SPDB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPDB115088-06-7ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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