ST-193 hydrochloride

Name: ST-193 hydrochloride
Brand: MedChemExpress
SKU: HY-101441A
Rating: 5.0 (4 reviews)

Cat. No.: HY-101441A Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

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ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC₅₀ values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

For research use only. We do not sell to patients.

ST-193 hydrochloride Chemical Structure

CAS No. : 2320274-72-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 264	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 264	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 116	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 648	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of ST-193 hydrochloride:

ST-193 In-stock

4 Publications Citing Use of MCE ST-193 hydrochloride

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC₅₀ values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

IC₅₀ & Target

IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)^[1]

In Vitro

ST-193 inhibits LASV pseudotypes with an IC₅₀ of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC₅₀s for Junín, Machupo, Guanarito, and Sabiá are in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

407.94

Formula

C₂₄H₂₆ClN₃O

CAS No.

2320274-72-2

Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(CNC2=CC=C3C(N=CN3C4=CC=C(OC)C=C4)=C2)C=C1)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 150 mg/mL (367.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1 mg/mL (2.45 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4513 mL	12.2567 mL	24.5134 mL
5 mM	0.4903 mL	2.4513 mL	4.9027 mL
10 mM	0.2451 mL	1.2257 mL	2.4513 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (250 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. [Content Brief]

[2]. Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75. [Content Brief]

[3]. Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9. [Content Brief]

Animal Administration
^[3]

Guinea pigs: ST-193 is formulated as a solution in 32% (w/v) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Female Hartley guinea pigs are injected intraperitoneally with a 10 mg/mL solution of ST-193 at a volume of either 2.5 mL per kg of body weight (25 mg/kg) or 10 mL per kg (100 mg/kg). Four animals per dose are used, with blood samples collected from two animals per dose at each time point in alternating fashion. Blood samples are obtained at the indicated time points (4-24 h)^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. [Content Brief]

[2]. Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75. [Content Brief]

[3]. Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.4513 mL	12.2567 mL	24.5134 mL	61.2835 mL
DMSO	5 mM	0.4903 mL	2.4513 mL	4.9027 mL	12.2567 mL
	10 mM	0.2451 mL	1.2257 mL	2.4513 mL	6.1284 mL
	15 mM	0.1634 mL	0.8171 mL	1.6342 mL	4.0856 mL
	20 mM	0.1226 mL	0.6128 mL	1.2257 mL	3.0642 mL
	25 mM	0.0981 mL	0.4903 mL	0.9805 mL	2.4513 mL
	30 mM	0.0817 mL	0.4086 mL	0.8171 mL	2.0428 mL
	40 mM	0.0613 mL	0.3064 mL	0.6128 mL	1.5321 mL
	50 mM	0.0490 mL	0.2451 mL	0.4903 mL	1.2257 mL
	60 mM	0.0409 mL	0.2043 mL	0.4086 mL	1.0214 mL
	80 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.7660 mL
	100 mM	0.0245 mL	0.1226 mL	0.2451 mL	0.6128 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.