ST-193

Name: ST-193
Brand: MedChemExpress
SKU: HY-101441
Rating: 5.0 (4 reviews)

Cat. No.: HY-101441 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC₅₀ values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

For research use only. We do not sell to patients.

ST-193 Chemical Structure

CAS No. : 489416-12-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 264	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 264	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 648	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 907	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1270	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of ST-193:

ST-193 hydrochloride In-stock

4 Publications Citing Use of MCE ST-193

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC₅₀ values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

IC₅₀ & Target

IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC₅₀	0.44 nM Compound: ST-193	Antiviral activity against Guanarito virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Guanarito virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay	[PMID: 23265895]
HEK-293T	EC₅₀	0.62 nM Compound: ST-193	Antiviral activity against Junin virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Junin virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay	[PMID: 23265895]
HEK-293T	EC₅₀	1.4 nM Compound: ST-193	Antiviral activity against Lassa virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Lassa virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay	[PMID: 23265895]
HEK-293T	EC₅₀	21 nM Compound: ST-193	Antiviral activity against Sabia virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Sabia virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay	[PMID: 23265895]
HEK-293T	EC₅₀	3.1 nM Compound: ST-193	Antiviral activity against Machupo virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Machupo virus pseudovirions infected in HEK293T/17 cells after 72 hrs by luciferase reporter gene assay	[PMID: 23265895]

In Vitro

ST-193 inhibits LASV pseudotypes with an IC₅₀ of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC₅₀s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

371.47

Formula

C₂₄H₂₅N₃O

CAS No.

489416-12-8

Appearance

Solid

Color

Off-white to pink

SMILES

CC(C1=CC=C(CNC2=CC=C3C(N=CN3C4=CC=C(OC)C=C4)=C2)C=C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (269.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6920 mL	13.4600 mL	26.9201 mL
5 mM	0.5384 mL	2.6920 mL	5.3840 mL
10 mM	0.2692 mL	1.3460 mL	2.6920 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (249 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. [Content Brief]

[2]. Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75. [Content Brief]

[3]. Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9. [Content Brief]

Animal Administration
^[3]

Guinea pigs: ST-193 is formulated as a solution in 32% (w/v) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Female Hartley guinea pigs are injected intraperitoneally with a 10 mg/mL solution of ST-193 at a volume of either 2.5 mL per kg of body weight (25 mg/kg) or 10 mL per kg (100 mg/kg). Four animals per dose are used, with blood samples collected from two animals per dose at each time point in alternating fashion. Blood samples are obtained at the indicated time points (4-24 h)^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. [Content Brief]

[2]. Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75. [Content Brief]

[3]. Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6920 mL	13.4600 mL	26.9201 mL	67.3002 mL
	5 mM	0.5384 mL	2.6920 mL	5.3840 mL	13.4600 mL
	10 mM	0.2692 mL	1.3460 mL	2.6920 mL	6.7300 mL
	15 mM	0.1795 mL	0.8973 mL	1.7947 mL	4.4867 mL
	20 mM	0.1346 mL	0.6730 mL	1.3460 mL	3.3650 mL
	25 mM	0.1077 mL	0.5384 mL	1.0768 mL	2.6920 mL
	30 mM	0.0897 mL	0.4487 mL	0.8973 mL	2.2433 mL
	40 mM	0.0673 mL	0.3365 mL	0.6730 mL	1.6825 mL
	50 mM	0.0538 mL	0.2692 mL	0.5384 mL	1.3460 mL
	60 mM	0.0449 mL	0.2243 mL	0.4487 mL	1.1217 mL
	80 mM	0.0337 mL	0.1683 mL	0.3365 mL	0.8413 mL
	100 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.6730 mL

ST-193 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-193489416-12-8ST193ST 193ArenavirusInhibitorinhibitorinhibit

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ST-193

Customer Review

Other Forms of ST-193:

ST-193 Related Antibodies

4 Publications Citing Use of MCE ST-193

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Protocol

Purity & Documentation

References

Customer Review

ST-193 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

ST-193 Related Classifications

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