2. Anti-infection
  3. Parasite Antibiotic Bacterial
  4. Secnidazole

Secnidazole  (Synonyms: RP-14539; PM-185184)

Cat. No.: HY-B1118 Purity: 99.87%
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Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis.

For research use only. We do not sell to patients.

Secnidazole Chemical Structure

Secnidazole Chemical Structure

CAS No. : 3366-95-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Secnidazole:

Secnidazole Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].

IC50 & Target

Amebae

 

Cellular Effect
Cell Line Type Value Description References
THP-1 IC50
> 1350 μM
Compound: 6
Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry
Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry
[PMID: 18590939]
In Vitro

Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively[2].
Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition[2].
Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2[2].
Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6[2].
Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Secnidazole Related Antibodies

Cell Viability Assay[3]

Cell Line: S.marcescens
Concentration: 10 μL (the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL)
Incubation Time: 20 h
Result: Had no inhibitory effect on S.marcescens growth at 2 mg/mL (equivalent to 1/5 MIC).
In Vivo

Secnidazole (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female healthy albino mice[3]
Dosage: 100 μL
Administration: 100 μL; ip.; for 5 days
Result: Significantly diminished the bacteria s capacity to kill mice.
Clinical Trial
Molecular Weight

185.18

Formula

C7H11N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C)CN1C([N+]([O-])=O)=CN=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (162.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 25 mg/mL (135.00 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4002 mL 27.0008 mL 54.0015 mL
5 mM 1.0800 mL 5.4002 mL 10.8003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (270.01 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.4002 mL 27.0008 mL 54.0015 mL 135.0038 mL
5 mM 1.0800 mL 5.4002 mL 10.8003 mL 27.0008 mL
10 mM 0.5400 mL 2.7001 mL 5.4002 mL 13.5004 mL
15 mM 0.3600 mL 1.8001 mL 3.6001 mL 9.0003 mL
20 mM 0.2700 mL 1.3500 mL 2.7001 mL 6.7502 mL
25 mM 0.2160 mL 1.0800 mL 2.1601 mL 5.4002 mL
30 mM 0.1800 mL 0.9000 mL 1.8001 mL 4.5001 mL
40 mM 0.1350 mL 0.6750 mL 1.3500 mL 3.3751 mL
50 mM 0.1080 mL 0.5400 mL 1.0800 mL 2.7001 mL
60 mM 0.0900 mL 0.4500 mL 0.9000 mL 2.2501 mL
80 mM 0.0675 mL 0.3375 mL 0.6750 mL 1.6875 mL
100 mM 0.0540 mL 0.2700 mL 0.5400 mL 1.3500 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Secnidazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Secnidazole3366-95-8RP-14539 PM-185184RP14539RP 14539PM185184PM 185184PM-185184ParasiteAntibioticBacterialoralazoleantibioticantimicrobialbacterialvaginosisGram-negativeGram-positiveanaerobicamoebiasisgiardiasisInhibitorinhibitorinhibit

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