Senazodan (Synonyms: MCI 154)

Cat. No.: HY-101693: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Senazodan (MCI 154) is a Ca²⁺ sensitiser, and also shows inhibition effect on PDE III.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Senazodan hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Senazodan Chemical Structure

CAS No. : 98326-32-0

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Other Forms of Senazodan:

Senazodan hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Senazodan (MCI 154) is a Ca²⁺ sensitiser, and also shows inhibition effect on PDE III^[1]^[2].

IC₅₀ & Target

PDE III^[1]

In Vitro

Senazodan seems to affect directly the actin-myosin crossbridge kinetics, and increase myosin ATPase activity^[1]. Senazodan produces a concentration-dependent increase in tension development. Senazodan enhances Ca²⁺ binding to myofilaments and to purified cardiac troponin C. Senazodan also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III^[2]. Senazodan (0.1 nM~0.1 mM) shows that the contractile response of superior mesenteric arterie (SMA) to norepinephrine (NE) after hemorrhagic shock is significantly decreased as compared with the normal control group. Senazodan (0.01 mM) pretreatment prevents the effects of Ang II, and the concentration-response curve of Ca²⁺ is shifted to the right as compared with Ang II-alone group^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Senazodan (0.1~2.0 mg/kg; left femoral vein catheterization infusion) decreases the pressor effect of norepinephrine (NE)^[3].
Senazodan (0.1 mg/kg; i.v.) makes LVSP, IP, MC, and Lo all increased significantly, while heart rate is not obviously changed and left ventricular end-diastolic pressure (LVEDP) is reduced remarkably^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats (200~250 g)^[3]
Dosage:	0.1~2.0 mg/kg
Administration:	Left femoral vein catheterization infusion
Result:	Decreased the pressor effect of norepinephrine (NE).

Animal Model:	Rabbits^[4]
Dosage:	0.1 mg/kg
Administration:	I.v.
Result:	LVSP, IP, MC, and Lo all were increased significantly while heart rate was not obviously changed and left ventricular end-diastolic pressure (LVEDP) was reduced remarkably.

Molecular Weight

266.30

Formula

C₁₅H₁₄N₄O

CAS No.

98326-32-0

SMILES

O=C1CCC(C2=CC=C(NC3=CC=NC=C3)C=C2)=NN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (93.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7552 mL	18.7758 mL	37.5516 mL
5 mM	0.7510 mL	3.7552 mL	7.5103 mL
10 mM	0.3755 mL	1.8776 mL	3.7552 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43(3):187-203. [Content Brief]

[2]. Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14(6):659-70. [Content Brief]

[3]. Yang G, et al. Effects of MCI-154 on vascular reactivity and its mechanisms after hemorrhagic shock in rats. J Cardiovasc Pharmacol. 2006;47(6):751-757. [Content Brief]

[4]. Ming MJ, et al. Effects of MCI-154, a calcium sensitizer, on cardiac dysfunction in endotoxic shock in rabbits. Shock. 2000;13(6):459-463. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7552 mL	18.7758 mL	37.5516 mL	93.8791 mL
	5 mM	0.7510 mL	3.7552 mL	7.5103 mL	18.7758 mL
	10 mM	0.3755 mL	1.8776 mL	3.7552 mL	9.3879 mL
	15 mM	0.2503 mL	1.2517 mL	2.5034 mL	6.2586 mL
	20 mM	0.1878 mL	0.9388 mL	1.8776 mL	4.6940 mL
	25 mM	0.1502 mL	0.7510 mL	1.5021 mL	3.7552 mL
	30 mM	0.1252 mL	0.6259 mL	1.2517 mL	3.1293 mL
	40 mM	0.0939 mL	0.4694 mL	0.9388 mL	2.3470 mL
	50 mM	0.0751 mL	0.3755 mL	0.7510 mL	1.8776 mL
	60 mM	0.0626 mL	0.3129 mL	0.6259 mL	1.5647 mL
	80 mM	0.0469 mL	0.2347 mL	0.4694 mL	1.1735 mL

Senazodan Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Senazodan98326-32-0MCI 154MCI154MCI-154Phosphodiesterase (PDE)Ca2+sensitiseractin-myosincrossbridgekineticsATPaseInhibitorinhibitorinhibit

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