2. Anti-infection
  3. Bacterial
  4. Squalamine lactate

Squalamine lactate  (Synonyms: MSI-1256F)

Cat. No.: HY-16467 Purity: 98.27%
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Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

For research use only. We do not sell to patients.

Squalamine lactate Chemical Structure

Squalamine lactate Chemical Structure

CAS No. : 320725-47-1

Size Price Stock Quantity
1 mg USD 450 In-stock
5 mg USD 880 In-stock
10 mg USD 1400 In-stock
50 mg USD 4480 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Squalamine lactate:

Squalamine lactate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

In Vitro

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Squalamine lactate Related Antibodies
In Vivo

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

718.04

Formula

C37H71N3O8S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NCCCCNCCCN[C@H]1CC[C@@]2(C)[C@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)([H])C1.C[C@@H](C(O)=O)O
Structure Classification
Initial Source

Squalus acanthias
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 36.66 mg/mL (51.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3927 mL 6.9634 mL 13.9268 mL
5 mM 0.2785 mL 1.3927 mL 2.7854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3927 mL 6.9634 mL 13.9268 mL 34.8170 mL
5 mM 0.2785 mL 1.3927 mL 2.7854 mL 6.9634 mL
10 mM 0.1393 mL 0.6963 mL 1.3927 mL 3.4817 mL
15 mM 0.0928 mL 0.4642 mL 0.9285 mL 2.3211 mL
20 mM 0.0696 mL 0.3482 mL 0.6963 mL 1.7409 mL
25 mM 0.0557 mL 0.2785 mL 0.5571 mL 1.3927 mL
30 mM 0.0464 mL 0.2321 mL 0.4642 mL 1.1606 mL
40 mM 0.0348 mL 0.1741 mL 0.3482 mL 0.8704 mL
50 mM 0.0279 mL 0.1393 mL 0.2785 mL 0.6963 mL
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Squalamine lactate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Squalamine320725-47-1MSI-1256FBacterialInhibitorinhibitorinhibit

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