2. Signaling Pathways
  3. Neuronal Signaling
  4. α-synuclein
  5. α-synuclein Degrader

α-synuclein Degrader

α-synuclein Degraders (5):

Cat. No. Product Name Effect Purity
  • HY-107811
    Harmol
    		Degrader 99.77%
    Harmol is a TFEB activator, an orally active monoamine oxidase inhibitor that has anti-tumor, anti-depressant, and anti-aging effects. Harmol can induce cell mitosis, autophagy and apoptosis. Harmol promotes the degradation of α-synuclein through the regulation of the autophagy-lysosomal pathway, improving motor deficits in mouse models of Parkinson's disease.
  • HY-157839
    PROTAC α-synuclein degrader 6
    		Degrader 99.28%
    PROTAC α-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with EC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research (Blue:ubiquitin E3 ligase cereblon ligand (HY-14658), Black: linker (HY-128803); Pink: Ligand for target protein (HY-151035)).
  • HY-136001
    PROTAC α-synuclein degrader 3
    		Degrader 99.35%
    PROTAC α-synuclein degrader 3 (compound 5) is a potent and selective PROTAC α-synuclein degrader. PROTAC α-synuclein degrader 3 can be used in research of Parkinson's disease.
  • HY-110174
    NAB2
    		Degrader 99.69%
    NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease.
  • HY-P10360
    Tat-βsyn-degron
    		Degrader
    Tat-βsyn-degron is an α-synuclein knockdown peptide that effectively degrades α-synuclein protein via the proteasome pathway. Tat-βsyn-degron effectively reduces α-synuclein protein levels in primary rat cortical neuron cultures. In a Parkinson's mouse toxicity model, Tat-βsyn-degron can alleviate parkinsonian toxin-induced neuronal damage and movement disorders.