NAB2

Name: NAB2
Brand: MedChemExpress
SKU: HY-110174
Rating: 4.5 (1 reviews)

Cat. No.: HY-110174 Purity: 99.69%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease.

For research use only. We do not sell to patients.

NAB2 Chemical Structure

CAS No. : 1504588-00-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 95	In-stock	Estimated Time of Arrival: April 10
Solution
10 mM * 1 mL in DMSO	USD 100	In-stock	Estimated Time of Arrival: April 10
Solid
1 mg	USD 58	In-stock	Estimated Time of Arrival: April 10
5 mg	USD 117	In-stock	Estimated Time of Arrival: April 10
10 mg	USD 191	In-stock	Estimated Time of Arrival: April 10
25 mg	USD 370	In-stock	Estimated Time of Arrival: April 10
50 mg	USD 590	In-stock	Estimated Time of Arrival: April 10
100 mg	USD 885	In-stock	Estimated Time of Arrival: April 10
200 mg		Get quote
500 mg		Get quote

Get it by April 10 for select sizes. Order within 12 hrs 41 mins.

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

α-synuclein

Molecular Weight

389.88

Formula

C₂₃H₂₀ClN₃O

CAS No.

1504588-00-4

Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C=C(C)C=C1)N2C3=CC=C(C(NCC4=C(C=CC=C4)Cl)=O)C=C3N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (256.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5649 mL	12.8245 mL	25.6489 mL
5 mM	0.5130 mL	2.5649 mL	5.1298 mL
10 mM	0.2565 mL	1.2824 mL	2.5649 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (245 KB) HNMR (210 KB) RP-HPLC (107 KB) LCMS (120 KB)

Handling Instructions (2659 KB)

References

[1]. Tardiff DF, et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979-983. [Content Brief]

[2]. Hatstat AK, et al. Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity. RSC Chem Biol. 2021 Nov 9;3(1):96-111. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5649 mL	12.8245 mL	25.6489 mL	64.1223 mL
	5 mM	0.5130 mL	2.5649 mL	5.1298 mL	12.8245 mL
	10 mM	0.2565 mL	1.2824 mL	2.5649 mL	6.4122 mL
	15 mM	0.1710 mL	0.8550 mL	1.7099 mL	4.2748 mL
	20 mM	0.1282 mL	0.6412 mL	1.2824 mL	3.2061 mL
	25 mM	0.1026 mL	0.5130 mL	1.0260 mL	2.5649 mL
	30 mM	0.0855 mL	0.4275 mL	0.8550 mL	2.1374 mL
	40 mM	0.0641 mL	0.3206 mL	0.6412 mL	1.6031 mL
	50 mM	0.0513 mL	0.2565 mL	0.5130 mL	1.2824 mL
	60 mM	0.0427 mL	0.2137 mL	0.4275 mL	1.0687 mL
	80 mM	0.0321 mL	0.1603 mL	0.3206 mL	0.8015 mL
	100 mM	0.0256 mL	0.1282 mL	0.2565 mL	0.6412 mL

NAB2 Related Classifications

Neurological Disease

Keywords:

NAB21504588-00-4NAB 2NAB-2α-synucleinα-Synα-synendosomal transportRsp5/Nedd4endosomalreticulum-to-Golgi vesicle traffickingInhibitorinhibitorinhibit

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NAB2

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Complete Stock Solution Preparation Table

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