2. Signaling Pathways
  3. Stem Cell/Wnt
  4. β-catenin
  5. β-catenin Degrader

β-catenin Degrader

β-catenin Degraders (4):

Cat. No. Product Name Effect Purity
  • HY-161719
    NF764
    		Degrader 99.28%
    NF764 is a potent β-catenin (CTNNB1) degrader. NF764 reduces CTNNB1 protein levels in a proteasome-dependent manner. NF764 can be used in the study of cancer.
  • HY-P5819
    xStAx-VHLL
    		Degrader 99.37%
    xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity.
  • HY-N11576
    Secalonic acid D
    		Degrader
    Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis.
  • HY-113680
    KY1022
    		Degrader
    KY1022 is a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway. KY1022 can inhibit cellular EMT, metastasis and apoptosis. KY1022 can be used for the research of metastatic colorectal cancer.