2. Stem Cell/Wnt PROTAC Cell Cycle/DNA Damage
  3. Wnt PROTACs β-catenin APC
  4. xStAx-VHLL

xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

xStAx-VHLL Chemical Structure

xStAx-VHLL Chemical Structure

Size Price Stock Quantity
1 mg USD 110 In-stock
5 mg USD 280 In-stock
10 mg USD 450 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of xStAx-VHLL:

xStAx-VHLL Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC–/– mice. xStAx-VHLL can be used as a promising anticancer agent[1].

Molecular Weight

3231.89

Formula

C154H244N48O29
Appearance

Solid

Color

White to off-white

Sequence

Ac-Arg-Arg-Trp-Pro-Arg-{S5}-Ile-Leu-Asp-{S5}-His-Val-Arg-Arg-Val-Trp-Arg-{Ahx}-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2
Sequence Shortening

Ac-RRWPR{S5}ILD{S5}HVRRVWR-{Ahx}-ALAPYIP-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (30.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3094 mL 1.5471 mL 3.0942 mL
5 mM 0.0619 mL 0.3094 mL 0.6188 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3094 mL 1.5471 mL 3.0942 mL 7.7354 mL
5 mM 0.0619 mL 0.3094 mL 0.6188 mL 1.5471 mL
10 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7735 mL
15 mM 0.0206 mL 0.1031 mL 0.2063 mL 0.5157 mL
20 mM 0.0155 mL 0.0774 mL 0.1547 mL 0.3868 mL
25 mM 0.0124 mL 0.0619 mL 0.1238 mL 0.3094 mL
30 mM 0.0103 mL 0.0516 mL 0.1031 mL 0.2578 mL
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xStAx-VHLL Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

xStAx-VHLLWntPROTACsβ-cateninAPCBeta cateninAnaphase promoting complexcolorectal cancerAPC–/– miceAPCmin/+ miceHEK293TBALB/C nude miceInhibitorinhibitorinhibit

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